Possible Interaction: Nitric Oxide and Resveratrol

“ Resveratrol increases the production of nitric oxide (NO) in endothelial cells by upregulating the expression of endothelial NO synthase (eNOS), stimulating eNOS enzymatic activity, and preventing eNOS uncoupling.”

“Researchers attribute one of the important blood pressure reducing mechanisms of resveratrol to increasing levels of NO.”

“ RSV considerably upregulated the plasma NO level in HFD mice.”

“… resveratrol … NO and PGE2 but did not reduce iNOS, TNF&agr; or IL‐1&bgr; gene expression in LPS‐stimulated RAW 264.7 for 18 h. … 6 h. Resveratrol and hydroxytyrosol 10 &mgr;M induced NRf2 nuclear translocation and reduced miR‐146a expression in LPS treated RAW 264.7.”

“They found that resveratrol significantly reduced the fibrosis score, nitric oxide and tumor necrosis factor-a levels, and increased the glutathione and superoxide dismutase levels in the hyperoxia group.”

“In this regard, resveratrol stimulates endothelial production of nitric oxide , reduces oxidative stress, inhibits vascular inflammation and prevents platelet aggregation.”

“ Resveratrol and its 3'-sulfate and 4-sulfate inhibit NO production by NO scavenging and down-regulation of iNOS expression in RAW 264.7 cells.”

“In cultured human umbilical vein endothelial cells (HUVECs), resveratrol (10-100 microM) concentration dependently enhanced phosphorylation of endothelial nitric oxide synthesis (eNOS) at Ser1177 and nitric oxide (NO) production.”

“In addition, resveratrol strongly inhibits nitric oxide generation and inducible nitric oxide synthase protein expression.”

“Recent in vitro and a limited number … have documented that physiological concentrations of resveratrol can modulate multiple molecular pathways thought to be associated with the development … disease and cancer, among them phase II drug metabolizing, cyclooxygenase, lipid metabolizing, nitric oxide , DNA-synthesis, inflammation, cell survival, … cell division cycle pathways.”