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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Nitric Oxide
supplement:
Polyunsaturated Fatty Acids
Research Papers that Mention the Interaction
“ PUFAs also augment the production of NO and inhibit the activity of angiotensin-converting enzyme and antagonize the actions of angiotensin II.”
Cytokines, angiogenic, and antiangiogenic factors and bioactive lipids in preeclampsia.“Higher post-intervention baseline NO level was observed after n-3 PUFA diet compared with placebo (23.5 ± 3.6 vs. 15.3 ± 3.0 µmol·l −1; P < 0.01, respectively).”
“The n-3 PUFA increased baseline NO concentration (ΔNO) by 6.7 ± 3.8 µmol·l−1 and placebo by 1.6 ± 4.4 µmol·l−1.”
“The fact that CLA alone or in combination with other PUFA modulated PGE2 and NO production in human OC cultures suggests that these 18∶2 isomers may have the potential to influence OA pathogenesis.”
“Findings suggest that PUFA modulates plasma and melatonin aortic NO levels of isoproterenol affected rats in a strain-dependent manner.”
Modulation of systemic and aortic nitric oxide by melatonin and n-3 polyunsaturated fatty acids in isoproterenol affected spontaneously hypertensive and normotensive Wistar rats.“In the same cultures, the supplement rich in PUFAs reduced the reactive oxygen species (ROS) and nitric oxide (NO) production.”
“We hypothesized that n-3 polyunsaturated fatty acid (PUFA) would reduce the production of inflammation mediators, including prostaglandin E(2) (PGE(2)) and NO , and related mRNA gene expression during osteoblastogenesis.”
“Monounsaturated FFAs such as oleic acid (OA) and polyunsaturated FFAs such as linoleic acid (LA) dose-dependently (10-100 Emol/L) inhibited NO release from BAECs stimulated by adenosine 5'-(3-O-thio)triphosphate (ATP AS) whereas saturated FFAs such as palmitic acid had no effect on NO release.”
“Suppression of NO production was observed with the omega 3 polyunsaturated fatty acids ( PUFAs ), docosahexaenoic acid, eicosapentaenoic acid and alpha-linolenic acid, in a dose-dependent fashion.”
“The inhibitory effect of omega 3 PUFA on NO production in activated macrophages could contribute to their cancer chemopreventive influence.”
“The addition of exogenous PGE2 or PGI2 (group B) ablated the difference in NO and TNF observed in group A. Indomethacin also (group … difference in NO and TNF production seen in omega 3- and omega 6-fed animals noted in group A. These data demonstrate that PUFA influence … NO ….”
“Exposure of rats to 10 ppm NO 2 for four weeks resulted in reduction of polyunsaturated fatty acids in the vitamin E-depleted group.”
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