Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Nitric Oxide and Polyphenols



Research Papers that Mention the Interaction

In studies using cultured vascular ECs, polyphenols were recognized to regulate nitric oxide and endothelin-1 (ET-1) production.
Nutrition  •  2015  |  View Paper
In addition to causing a rapid and sustained activation of eNOS by phosphorylation, polyphenols can increase the expression level of eNOS in endothelial cells leading to an increased formation of NO.
Pflügers Archiv - European Journal of Physiology  •  2010  |  View Paper
Pomegranate extract (POMx) has been suggested as an ergogenic aid due to its rich concentration of polyphenols , which are proposed to enhance nitric oxide bioavailability, thereby improving the efficiency of oxygen usage and, consequently, endurance exercise performance.
International journal of sport nutrition and exercise metabolism  •  2018  |  View Paper
Evidence suggests that dietary polyphenols or their metabolites act as signalling molecules and can increase nitric oxide bioavailability and induce protective enzymes.
Archives of biochemistry and biophysics  •  2016  |  View Paper
In this paper we propose a short-cut for the systemic effects of polyphenols in connection with nitric oxide (˙NO) biology.
Food & function  •  2014  |  View Paper
Indeed, polyphenols have been shown to be potent stimulators of endothelial vasoprotective mechanisms including the formation of nitric oxide (NO) and the induction of endothelium-derived hyperpolarization (EDH).
Current pharmaceutical design  •  2014  |  View Paper
In addition, we describe how the vasoprotective effect of dietary polyphenols has been related to their ability to increase endothelial synthesis of nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF)-mediated responses.
Mini reviews in medicinal chemistry  •  2013  |  View Paper
There is mounting evidence that specific dietary polyphenols can enhance vascular health by augmenting nitric oxide.
Journal of agricultural and food chemistry  •  2012  |  View Paper
Our data suggest that polyphenols can decrease vascular inflammation by increasing the synthesis of NO , which blocks endothelial exocytosis.
Biological chemistry  •  2008  |  View Paper
Grape extracts or a mixture of the polyphenols contained in wine were previously shown to increase nitric oxide (NO); however, little information is available on the effect of resveratrol, one of the main polyphenols of wine, on platelet NO production.
The Journal of nutrition  •  2008  |  View Paper
Show More