Possible Interaction: Nitric Oxide and Polyphenols

“In studies using cultured vascular ECs, polyphenols were recognized to regulate nitric oxide and endothelin-1 (ET-1) production.”

“In addition to causing a rapid and sustained activation of eNOS by phosphorylation, polyphenols can increase the expression level of eNOS in endothelial cells leading to an increased formation of NO.”

“We found that polyphenols and particularly flavonoids are able to markedly attenuate NO production and iNOS expression through the nuclear factor κB (NF-κB) and JAK/STAT signaling pathways.”

“Pomegranate extract (POMx) has been suggested as an ergogenic aid due to its rich concentration of polyphenols , which are proposed to enhance nitric oxide bioavailability, thereby improving the efficiency of oxygen usage and, consequently, endurance exercise performance.”

“Evidence suggests that dietary polyphenols or their metabolites act as signalling molecules and can increase nitric oxide bioavailability and induce protective enzymes.”

“In this paper we propose a short-cut for the systemic effects of polyphenols in connection with nitric oxide (˙NO) biology.”

“Indeed, polyphenols have been shown to be potent stimulators of endothelial vasoprotective mechanisms including the formation of nitric oxide (NO) and the induction of endothelium-derived hyperpolarization (EDH).”

“In addition, we describe how the vasoprotective effect of dietary polyphenols has been related to their ability to increase endothelial synthesis of nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF)-mediated responses.”

“There is mounting evidence that specific dietary polyphenols can enhance vascular health by augmenting nitric oxide.”

“Our data suggest that polyphenols can decrease vascular inflammation by increasing the synthesis of NO , which blocks endothelial exocytosis.”