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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nitric Oxide
supplement:
Palmitic Acid
Research Papers that Mention the Interaction
“The isolated compounds Oleic acid (3), Palmitic acid (4), desmethylisoophiopogonone B [5,7-dihydroxy-3-(4′-hydroxybenzyl)-8- methyl- chromone] (5), 5,7-dihydroxy-6-methyl-3-(4′-hydroxybenzyl) chromone (7) and 10 significantly suppressed the production of NO in LPS-induced RAW 264.7 cells.”
Evaluation of anti-inflammatory activity of compounds isolated from the rhizome of Ophiopogon japonicas“ PA decreased the production of NO , and the levels of phosphorylated-eNOS, whereas knockdown of CCN1 partially abrogated these effects triggered by PA.”
“ PA reduced eNOS Ser1177 , nNOS Ser1417 , and NO level in HTN-LA but exerted no effect in sham-LA.”
Reduced nNOS activity is responsible for impaired fatty acid–dependent mitochondrial oxygen consumption in atrial myocardium from hypertensive rat“Conclusions: In summary, palmitic acid stimulates NO production in cultured skeletal muscle cells through production of superoxide, nuclear factor-kappa B activation and increase of iNOS protein content.”
“Results: Palmitic acid treatment increased nitric oxide production.”
“It was revealed that PA treatment resulted in a significant increase in ROS generation and autophagic activity, leading to endothelial dysfunction as indicated by downregulated nitric oxide synthesis, decreased capillary-like structure formation and damaged cell repair capability.”
Palmitic acid-induced autophagy increases reactive oxygen species via the Ca2+/PKCα/NOX4 pathway and impairs endothelial function in human umbilical vein endothelial cells
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