Possible Interaction: Nitric Oxide and Oxytocin

“In another study we demonstrated that NO reduces oxytocin as well as vasopressin secretion from the posterior pituitary, suggesting it has a modulatory role during dehydration.”

“Within the hypothalamo-hypophyseal system, NO exerts an inhibitory effect in the control of oxytocin secretion.”

“ Nitric oxide in turn causes, by a mechanism that is as yet unidentified, the release of oxytocin in extra-hypothalamic brain areas.”

“ NO in turn activates, by a mechanism that is as yet unidentified, the release of oxytocin from oxytocinergic neurons in extrahypothalamic brain areas.”

“ Nitric oxide (NO) tonically inhibits the basal release of vasopressin and oxytocin into plasma.”

“Second, dopamine agonists, NMDA and oxytocin given at doses that induce yawning, increase NO production in the PVHN, as determined by in vivo microdialysis.”

“Dopamine agonists, NMDA and oxytocin increase NO production in the PVN at doses that induce penile erection and yawning, as determined by measuring the concentration of NO2- and NO3- in the dialyzate obtained with a vertical probe implanted in the PVN by in vivo microdialysis.”

“Recent evidence implicates NO as a modulator of endocrine secretions, with inhibition of insulin, growth hormone (GH) and oxytocin release and stimulation of vasopressin (AVP), adrenocorticotropin (ACTH) and corticotropin releasing hormone (CRH) release.”

“It is possible that nitric oxide , but not GABA, may contribute to the feedback system of OXT neurons in chronic inflammation.”

“… NO ) negatively modulates … vasopressin (AVP), oxytocin (OT) and atrial natriuretic peptide (ANP) induced by the increase in extracellular osmolality, whereas carbon monoxide (CO) and hydrogen sulphide (H2S) act … it; however, little information is available for the osmotic challenge model about whether and how such gaseous systems modulate each other.”