Possible Interaction: Nitric Oxide and Oligosaccharides

“In vitro results further confirmed that 2'-FL or HMO treatment reduced allergen-induced secretion of iNOS, NO , pro-inflammatory cytokines and reactive oxygen species in RAW264.7 cells.”

“In this report, we initially demonstrated that AGOs intake inhibited NO production in activated peritoneal macrophages.”

“We have previously reported that agaro-oligosaccharides (AGOs) suppressed the elevated levels of nitric oxide (NO), prostaglandin E₂(PGE₂), and pro-inflammatory cytokines in activated monocytes/macrophages, via heme oxygenase-1 induction.”

“We demonstrate that agaro-oligosaccharides suppressed the elevated levels of nitric oxide , prostaglandin E2, and such pro-inflammatory cytokines as tumor necrosis factor-α, interleukin-1β and interleukin-6 in lipopolysaccharide-stimulated monocytes and macrophages.”

“The … that CPO could increase immune organ indices, phagocytic index and immunoglobulin contents, stimulate the proliferation of splenic lymphocytes (… ConA and LPS), enhance the earlap swelling of the DTH reaction, promote the production of NO and cytokines (IL-2 and IFN-γ) … upregulate the expression of the corresponding mRNA.”

“We showed that COS stimulated the production of TNF-alpha, NO and the released RDPase.”

“The OE (0.3 mg total sugar/mL) induced a rapid production of NO in cultures, which exhibited a biphasic time course, reaching the first plateau within 1.5 h and the second within 8 h of OE treatment.”