Possible Interaction: Nitric Oxide and Naringenin

“Sakuranetin and (−)-naringenin , which were present in an ethyl acetate-soluble fraction of the bark extract, significantly inhibited NO induction and inducible nitric oxide synthase (iNOS) expression.”

“Importantly, apigenin and naringenin significantly increased NO production in endothelial cells subjected to high glucose challenge.”

“On immunomodulatory properties, catechin, epigallocatechin (EGC), naringenin , and fisetin repressed NO production and TNF-a secretion.”

“In vitro treatment with naringenin led to a significant attenuation in the LPS-induced NHBE secretion of tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), superoxidase dismutase (SOD), nitricoxide synthase (NOS), myeloperoxidase (MPO), and nitric oxide ( NO).”

“However, the inefficacy of naringenin on NO production remains to be elaborately studied.”

“In addition, NGN inhibited the production of NO and trigged the synthesis of antioxidant marker enzymes.”

“In this study, we demonstrated that naringenin inhibites the release of nitric oxide (NO), the expression of inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2), as well as pro-inflammatory cytokines in microglial cells.”

“Compound II and compound VI had no anti-inflammatory activity with concentration at 50 g/mL. Sativanone, isoliquiritigenin, liquiritigenin and naringenin at their concentrations ranging from 3.125-50 g/mL, could inhibit NO release in RAW264.7 cells stimulated by LPS.”

“Also, naringenin attenuated the elevated levels of lipid peroxidation and nitric oxide , and restored the level of reduced glutathione.”

“We found that pre-treatment with naringenin prior to treatment with LPS significantly inhibited excessive production of nitric oxide ( NO ) and prostaglandin E2 (PGE2) in a dose-dependent manner.”