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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nitric Oxide
supplement:
Myricetin
Research Papers that Mention the Interaction
“ Myricetin administration decreased the production of NO , iNOS, TNF-α, IL-6, and IL-12 in mice.”
“ Myricetin dose-dependently suppressed the production of pro-inflammatory mediators ( NO , iNOS, PGE2, and COX-2) in LPS-stimulated RAW264.7 macrophages.”
Anti-inflammatory activity of myricetin from Diospyros lotus through suppression of NF-κB and STAT1 activation and Nrf2-mediated HO-1 induction in lipopolysaccharide-stimulated RAW264.7 macrophages“AE, myricitrin and myricetin inhibited NO (320 μg/mL and 6.25-100 μM, respectively) and TNF-α production by macrophages (320 μg/mL for AE, 100 μM for myricitrin and 25-100 μM for myricetin).”
“ Myricetin decreased the production of nitric oxide (NO), myeloperoxidase (MPO) and malondialdehyde (MDA), while increasing the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px).”
“As both kaempferol and myricetin are known as inhibitors of inducible nitric oxide synthase expression, our results suggest that modifications of nitric oxide level in tissues by these compounds cannot be predicted from data about its effects on nitric oxide synthase expression or activity.”
“ Myricetin decreased nitric oxide production in intact rat liver.”
“Phenolic compounds at the range of 16-500 microM that inhibited NO production by > 50% without showing cytotoxicity were the flavonols quercetin and myricetin , the isoflavone daidzein, and the anthocyanins/anthocyanidins pelargonidin, cyanidin, delphinidin, peonidin, malvidin, malvidin 3-glucoside, and malvidin 3,5-diglucosides.”
“…,myricetin , leucocyanidol, and oligomeric … highest increases in nitric oxide release (&Dgr;[NO] > 8.5 n M); caffeic acid, fisetin, hyperosid, and isoquercitrin were moderately active (5 n M < &Dgr;[NO] < … M); the other phenolic compounds caused only marginal increases of the nitric oxide levels (&Dgr;[NO] < 5 n M).”
“We found that myricetin significantly downregulated several markers of the neuroinflammatory response in LPS-induced activated microglia, including inducible nitric oxide (NO) synthase (iNOS), cyclooxygenase-2 (COX-2), and proinflammatory modulators and cytokines such as prostaglandin E2 (PGE2), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α).”
Inhibitory Effects of Myricetin on Lipopolysaccharide-Induced Neuroinflammation
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