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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Nitric Oxide
supplement:
Methylsulfonylmethane
Research Papers that Mention the Interaction
“ MSM significantly increased the levels of glutathione (GSH), catalase (CAT) and prostaglandin E2 (PGE2), and decreased the levels of malondialdehyde (MDA), myeloperoxidase (MPO), carbonyl protein, and nitric oxide ( NO ) in gastric tissues compared with those in the ethanol group.”
Methylsulfonylmethane is effective against gastric mucosal injury.“Since excess nitric oxide production causes apoptosis of macrophages, anti-apoptotic effects of MSM are thought to be mediated by its inhibitor effects on inducible nitric oxide synthase (iNOS) protein and nitric oxide levels.”
“ MSM significantly inhibited the release of nitric oxide and prostaglandin E(2) by alleviating the expression of inducible nitric oxide synthase and cyclooxygenase-2 in LPS-stimulated RAW264.7 cells.”
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