Possible Interaction: Nitric Oxide and Masoprocol

“Exposure of BAECs to NDGA enhanced NO production, as measured by electron paramagnetic resonance spin trapping and eNOS activity, as measured by [14C]arginine-to-[14C]citrulline assay.”

“These results indicate that dexamethasone, 4-BPB, NDGA and ethacrynic acid inhibited the production of NO by macrophages through at least two different mechanisms: one was inhibited by dexamethasone, NDGA and ethacrynic acid and the other by 4-BPB.”

“ MDGA and licarin A diminished the calcium influx that routinely accompanies with the glutamate‐induced neurotoxicity, and inhibited the subsequent overproduction of cellular nitric oxide and peroxide to the level of control cells.”

“LOX inhibitors nordihydroguaiaretic acid and baicalein), but not cyclooxygenase (indomethacin) or epoxygenase (clotrimazole) ones, prevent cell death in the culture, even when added 10 h after NO treatment.”

“The LO inhibitor nordihydroguaiaretic acid (NDGA) decreased IL-stimulated NO and iNOS synthesis.”

“By contrast, nordihydroguaiaretic acid NDGA ) inhibited production of leukotrienes, PGE2 and NO only at doses that were cytotoxic to the RAW cells.”

“Since nordihydroguaiaretic acid also interferes with signal transduction involving NO , we next examined whether inhibitors of NO synthase block LTP.”

“The administration of the EDRF inhibitors ETYA, NDGA , and HQ resulted in a marked accentuation of the hypoxic pressor response that was not seen in the controls (P less than 0.05).”

“ Nordihydroguaiaretic acid was less effective against the formation of canine EDRF than of rabbit EDRF.”