Possible Interaction: Nitric Oxide and Lycopene

“Moreover, lycopene significantly reduced the level of iNOS, nNOS, and NO in the brain.”

“Hovewer, Lyc combined with Mel provided a significant reduction also in NO levels.”

“The reactive oxygen species (ROS) generation and inducible nitric oxide synthetase expression were also inhibited dose-dependently by lycopene.”

“These results suggest that lycopene exhibit a neuroprotective effect by accelerating brain anti-oxidant defense mechanisms and down regulating nitric oxide pathways.”

“… lycopene inhibited … oxide ( NO ) and interleukin-6 (IL-6) in murine RAW264.7 macrophages by mechanisms related to inhibition of ERK and nuclear factor-κB. Since the … (TLR4) in lipid rafts is a key element in LPS induced signaling, we investigated whether this process would be influenced by lycopene.”

“ Lycopene also inhibited the TNF‐α and NO release in a dose dependent manner.”

“These results indicate an antinociceptive activity of lycopene possibly through its inhibitory action on NO and TNF‐α release and point towards its potential to attenuate diabetic neuropathic pain.”

“Conclusions: The present data demonstrate that lycopene increases NO generation and release, as shown by the increase in NO and nitrite/nitrate concentrations, by preventing peroxynitrite formation.”