Possible Interaction: Nitric Oxide and Linolenic Acid

“ No ' protective' effect of linoleic, linolenic or eicosapentaenoic acid was demonstrable.”

“Inhibitory effect of ALA on generation of NO and cytokines was mediated by down-regulation of inducible nitric oxide synthase and cyclooxygenase-2 protein and mRNA expressions.”

“CONCLUSIONS: P. oleracea and ALA , as well as dexamethasone, decreased NO and MDA levels but increased antioxidant agents in human lymphocytes.”

“Treatment with a ω-3 fatty acid α-linolenic acid (ALA, 50 μmol/L) produced moderate reduction in LPS-stimulated inflammatory cytokines and NO production (TNF-α and IL-6 were decreased by 46% and 42%, respectively).”

“We hypothesized that dietary α-linolenic acid (ALA, 18:3 n-3) favors NO availability by modulating amino acid metabolism, with a specific impact on the arginine–NO pathway.”

“We found that ALA has a strong inhibitory effect on the production of NO.”

“Suppression of NO production was observed with the omega 3 polyunsaturated fatty acids (PUFAs), docosahexaenoic acid, eicosapentaenoic acid and alpha-linolenic acid , in a dose-dependent fashion.”

“ ALA decreased the levels of malondialdehyde and nitric oxide , enhanced glutathione content, and increased the activity of catalase in the hippocampus of the rat model of AD.”

“The results showed that the treatment with 10 microL/L NO significantly increased the contents of the palmitoleic (16:1), oleic (18:1), and linolenic (18:3) acid in phospholipid (PL), while it decreased the contents of linoleic (18:2) acid in PL.”