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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nitric Oxide
supplement:
L-Epicatechin
Research Papers that Mention the Interaction
“ NO pronouncedly depressed EC gene expression, in particular of transcription factors.”
Nitric oxide donor induces temporal and dose-dependent reduction of gene expression in human endothelial cells.“ Epi and Epi + Norv decreased nitrosylated Ar levels by ∼25% in aged cells with lower oxidative stress (∼25%) (dihydroethidium) levels.”
Arginase inhibition by (−)-Epicatechin reverses endothelial cell aging“… (−)-epicatechin was also prevented … of L-NAME [ nitric oxide (NO) synthase inhibitor], 7-nitroindazole (neuronal NO synthase inhibitor), ODQ (guanylyl cyclase inhibitor), glibenclamide (ATP-sensitive K+ channel blocker), 4-…+ channel blocker), and iberiotoxin (large-conductance Ca2+-activated K+ channel blocker), but not by amiloride (acid sensing ion channel blocker).”
“In the aorta, Epi significantly increased nitric oxide (NO) synthase (NOS) activity and elevated the NO-dependent vasorelaxation.”
“These results give further support to the concept that (–)‐epicatechin can modulate BP in hypertension by increasing NO levels in the vasculature.”
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