A new horizon into the pathobiology, etiology and treatment of migraine.

 stimulates nitric oxide synthase producing more 

 which is inhibited by zinc, thus, antagonizing peroxynitrite generation.

Iron Chelation Improves Endothelial Function in Patients With Coronary Artery Disease

Glutathione S-transferase and MRP1 form an integrated system involved in the storage and transport of dinitrosyl-dithiolato iron complexes in cells.

 possesses a rich coordination chemistry with 

 and the formation of dinitrosyl-dithiolato iron complexes (DNICs) is well documented.

Re: Pierce et al. Diacetyl and 2,3-pentanedione exposures associated with cigarette smoking: implications for risk assessment of food and flavoring workers Crit Rev Toxicol, 2014; 44(5):420–435

Workers, who were current smokers, had signifi cantly lower

 levels when compared with nonsmokers ( p 0.01).

Discovery of nitric oxide and cyclic GMP in cell signaling and their role in drug development

 can interact with transition metals such as 

, thiol groups, other free radicals, oxygen, superoxide anion, unsaturated fatty acids, and other molecules.

The dual function of nitrite under stomach conditions is modulated by reducing compounds.

from nitrite only up to pH 3, but the addition of

Nitrogen monoxide (NO)-mediated iron release from cells is linked to NO-induced glutathione efflux via multidrug resistance-associated protein 1

Multifunctional Activities of Green Tea Catechins in Neuroprotection

 gradient in conjunction with ROS (superoxide, hydroxyl radical and 

) are thought to constitute a major trigger in neuronal toxicity and demise in all these diseases.

The basics about nitric oxide.

Differential effects on cellular iron metabolism of the physiologically relevant diatomic effector molecules, NO and CO, that bind iron.

 uptake from transferrin (Tf) and increase Fe mobilisation from cells [J. Biol.

Discovery of Some of the Biological Effects of Nitric Oxide and its Role in Cell Signaling

, thiol groups, other free radicals, oxygen, superoxide anion, unsaturated fatty acids and other molecules.

Nitric oxide and iron: effect of iron overload on nitric oxide production in endotoxemia.

A number of studies have described the complex relationships between iron and NO, but controversy remains as to the influence and significance of

The mechanism of nitrogen monoxide (NO)-mediated iron mobilization from cells. NO intercepts iron before incorporation into ferritin and indirectly mobilizes iron from ferritin in a glutathione-dependent manner.

, and we showed that NO-mediated Fe mobilization is markedly potentiated by glutathione (GSH) generated by the hexose monophosphate shunt [Watts, R.N. & Richardson, D.R. (2001) J. Biol.

Antioxidant mechanisms of nitric oxide against iron-catalyzed oxidative stress in cells.

 to prevent their catalytic prooxidant reactions.

Can we just say NO to sickle cell anemia?

Nonreversible NO binding and NO-induced oxidation occur in 2 steps: (a) bimolecular entry of NO into the distal portion of the heme pocket, and (b) rapid reaction of noncovalently bound

Discovery of some of the biological effects of nitric oxide and its role in cell signaling.

Nitric oxide and mitochondrial respiration.

 can inhibit the other respiratory chain complexes, probably by nitrosylating or oxidising protein thiols and removing 

Nitric oxide signaling: would you believe that a simple free radical could be a second messenger, autacoid, paracrine substance, neurotransmitter, and hormone?

, thiol groups, other free radicals, oxygen, superoxide anion, unsaturated fatty acids, and other reactive species.

Dynamic aspects of nitric oxide metabolism in the circulation and tissues.

 forms dissociable complexes with thiols and 

 forms dissociable complexes with various thiols and 

, such as guanylate cyclase and hemoglobin (Hb), thereby regulating vascular resistance, platelet aggregation, neurotransmission, and diverse functions of tissues.

Nitric oxide and oxidative stress (H2O2) control mammalian iron metabolism by different pathways

In particular, we suggest the possibility that

 availability rather than the iron-sulfur cluster of IRP-1.

Nitric oxide donors modulate ferritin and protect endothelium from oxidative injury.

 inhibits the increase of EC ferritin after exposure to 

 but provides short-term protection against oxidants; ferritin, in turn, provides durable cytoprotection by inactivating reactive iron.

Nitric oxide and synaptic function.

Although the targets of NO have not yet been completely described, it is known that

 contained in heine groups, leading to conformational changes in associated proteins, such as guanylyl cyclase.

Nitric Oxide: A Physiologic Messenger

 in the heme group of guanylate cyclase, the enzyme is activated.

Nitrosyl iron complexes--synthesis, structure and biology.

 are formed in living species in the presence of 

Treatment of Anemia in Heart Failure: Potential Risks and Benefits of Intravenous Iron Therapy in Cardiovascular Disease

 is a known pro-oxidant factor that can inhibit 

 signaling and irreversibly injury cells.

Soluble guanylate cyclase: not a dull enzyme.

 changes the conformation of the enzyme and leads to a >100-fold increase in catalytic rate (ie, the conversion of guanosine triphosphate to the second messenger cyclic guanosine monophosphate [cGMP]).

Free radicals act as effectors in the growth inhibition and apoptosis of iron-treated Burkitt's lymphoma cells

 catalyzes the formation of highly reactive compounds such as hydroxyl radicals and 

 (NO) that damages macromolecular components of cells, eventually resulting in apoptosis.

 increased the intracellular levels of peroxide/peroxynitrite and 

The specific NOS2 inhibitor, 1400W, sensitizes HepG2 cells to genotoxic, oxidative, xenobiotic, and endoplasmic reticulum stresses.

The mechanism of this … involve the complexing of

) to reduce hydroxyl radical formation, NO inhibition of electron transport and the generation of reactive oxygen species within mitochondria, … of cyclooxygenase, lipoxygenase, and cytochrome P450 enzyme activity, and the scavenging of superoxide anions by NO to form peroxynitrite.

The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells.

 uptake from Tf by a mechanism separate to its effects on IRP1, and NO may also be responsible for activated macrophage-mediated Fe release from target cells.

Effect of nitric oxide on expression of transferrin receptor and ferritin and on cellular iron metabolism in K562 human erythroleukemia cells.

 alone did not alter intracellular ferritin levels, but it did abrogate the inhibitory effect of the iron chelator desferrioxamine and potentiated the stimulatory effect of additional 

Endothelial dysfunction induced by hydroxyl radicals - the hidden face of biodegradable Fe-based materials for coronary stents.

 production was also reduced by HO generated during 

 corrosion, as indicated by the protective role of catalase.

Exposure to excess dissolved iron in vivo affects oxidative status in the bivalve Mya arenaria.

, assessed by EPR spin trapping, was 60% lower in DG of animals exposed for 2days to 

 than in control values, with no further changes.

Labile iron pool and ferritin content in developing rat brain gamma-irradiated in utero.

The data presented in this work are the first experimental evidence suggesting that, as part of the network of the cellular response to limit irradiation-dependent injury, a complex interaction between

Nitric oxide synthesis inhibition attenuates iron-induced neurotoxicity: a stereological study.

Results of the present study suggest that inhibition of

 synthesis may attenuate the neurotoxic effects of 

Estrogen enhances the inhibitory effect of iron on microglial nitric oxide production.

The present results demonstrated that exposure of microglia to

 significantly decreased lipopolysaccaride-induced 

 production, as determined by nitrite accumulation in the cell culture medium, and such effect of iron was potentiated by increasing concentration of estrogen.

Inflammatory modulation of hepatocyte apoptosis by nitric oxide: in vivo, in vitro, and in silico studies.

, oxygen, and superoxide may dictate whether 

Iron down‐regulates macrophage anti‐tumour activity by blocking nitric oxide production

 on macrophage production of tumoricidal free radical nitric oxide (

) has been reported, its possible influence on macrophage anti‐tumour activity has not been established.

 production and increased the viability of L929 fibrosarcoma cells stimulated with IFN‐γ + LPS in the absence of macrophages.

Substrate binding favors enhanced NO binding to P450cam.

 contribute significantly to the observed volume effects.

[Effect of nitric oxide on iron metabolism in rats with anemia of chronic disease].

 plays an important role in pathogenesis of ACD and influences the regulation of 

Haem and nitric oxide: synergism in the modulation of the endothelial haem oxygenase-1 pathway.

 potently up-regulates vascular haem oxygenase-1 (HO-1), an inducible defensive protein that degrades haem to CO, 

Iron hemiporphycene as a functional prosthetic group for myoglobin.

This observation suggests that the in-plane configuration of the

In vivo fate of superparamagnetic iron oxides during sepsis.

 (NO) in vivo has been reported to be modulated by ions, such as copper and 

Superoxide activates constitutive nitric oxide synthase in a brain particulate fraction.

) can act as an antioxidant by directly scavenging reactive free radicals, inhibiting the oxidative chemistry of 

, and signaling the up-regulation of antioxidant enzymes.

Characterization of a novel brain‐derived microglial cell line isolated from neonatal rat brain

Our studies demonstrate that both iron chelation and

 loading diminished the LPS‐induced effect of TNF‐α and 

Experimental evidence suggesting that nitric oxide diffuses from tissue into blood but not from blood into tissue.

 in the tissues resulted in a reduction of Hb--NO levels in blood accompanied by the formation of water-insoluble DETC--Fe-NO complexes in ischemic intestine and normoxic tissues both during ischemia and during reperfusion.

Nitric oxide up‐regulates ferritin mRNA level in snail neurons

In conclusion, our findings show that Helix neurons express an intracellular H‐ferritin isoform and suggest that

Cellular Non-heme Iron Content Is a Determinant of Nitric Oxide-mediated Apoptosis, Necrosis, and Caspase Inhibition*

 loading was also associated with the formation of intracellular dinitrosyl-iron complexes (DNIC) upon 

Examination of the mechanism of action of nitrogen monoxide on iron uptake from transferrin.

 uptake by a number of mechanisms, the decrease in ATP levels appears, at least in part, to play a role.

In this study we examined the possible mechanisms whereby

Influence of nitric oxide on cellular and mitochondrial integrity in oxidatively stressed astrocytes.

Iron-loading increases peroxide-induced oxidative stress in astrocytes, but induction of NO limited the iron effect, suggesting an interaction between

Regulation of iron metabolism in murine J774 macrophages: role of nitric oxide-dependent and -independent pathways following activation with gamma interferon and lipopolysaccharide.

Addition of the NO synthase (NOS) inhibitor N-monomethyl arginine (NMMA) partially restored Fe uptake but either had no effect on or downregulated TfR expression, which suggests that

Effect of nitric oxide on iron‐mediated oxidative stress in primary rat hepatocyte culture

In addition, using NG‐monomethyl‐L‐arginine (L‐NMMA), a NO synthase inhibitor,

 was shown to be involved in the inhibition of oxidative stress induced by 

Iron potentiates nitric oxide scavenging by dithiocarbamates in tissue of septic shock mice.

Acta 1269 (1995) 19-24) reported that short term (30 min)

 (NO) production in tissues of septic shock mice, based on increased formation of NO complex by diethyldithiocarbamate (DETC).

Effects of the ferritin open reading frame on translational induction by iron.

 on ferritin expression are cytokines, such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), nitric oxide (

Intracellular Assembly of Inducible NO Synthase Is Limited by Nitric Oxide-mediated Changes in Heme Insertion and Availability

Measurement of iron release from activated cells demonstrated that endogenous

 synthesis substantially increased the release of 

EPR detection of heme and nonheme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft.

 production results in a characteristic pattern of alteration of 

 enzyme function that is mimicked by exposure to NO.

Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide.

IL-1 beta induces the formation of an iron-dinitrosyl complex by Rin-m5F cells indicating that

 mediates the destruction of iron-sulfur clusters of 

Macrophage cytostatic effect on Trypanosoma musculi involves an L-arginine-dependent mechanism.

 reversed the trypanostatic effect of both macrophages and 

Mycobacterium tuberculosis SufR responds to nitric oxide via its 4Fe–4S cluster and regulates Fe–S cluster biogenesis for persistence in mice

–S clusters to exhaust respiratory and redox buffering capacity of MtbΔsufR. Lastly, MtbΔsufR failed to recover from a NO-induced non-growing state and displayed persistence defect inside immune-activated macrophages and murine lungs in a NO-dependent manner.

Evidences for a role of nitric oxide in iron homeostasis in plants.

 uptake mechanisms but it also makes it more bioavailable for metabolic functions.

 which can then be delivered into target cells/ tissues.

Manganese import protects Salmonella enterica serovar Typhimurium against nitrosative stress.

 and magnesium all decrease in response to 

 while cellular manganese increases significantly.

Guest encapsulations in non-porous crystals of fully fluorinated dinuclear metal complexes with the M2O2 core (M = Fe3+, Co2+, Ni2+).

 in high amounts and the complex of cobalt is found to store adsorbed O2.

Excess iron stress reduces root tip zone growth through nitric oxide-mediated repression of potassium homeostasis in Arabidopsis.

 in root tips is increased significantly above levels elsewhere in the … in the arrest of primary root tip zone growth under excess 

, at least in part related to NO-induced K+ loss via SNO1 (sensitive …)/SOS4 (salt overly sensitive 4) and reduced root tip zone cell viability.

Nitric Oxide and Iron Signaling Cues Have Opposing Effects on Biofilm Development in Pseudomonas aeruginosa

The results presented here suggest that the presence of

 represents one such environmental cue that antagonizes the activity of 

Iron-induced nitric oxide leads to an increase in the expression of ferritin during the senescence of Lotus japonicus nodules.

Simultaneous NOx and Particulate Matter Removal from Diesel Exhaust by Hierarchical Fe-Doped Ce–Zr Oxide

 ions and associated oxygen vacancies catalyze facile 

Carbon Monoxide Interacts with Auxin and Nitric Oxide to Cope with Iron Deficiency in Arabidopsis

On the other hand, the treatments of exogenous CO and

Hemilabile Bridging Thiolates as Proton Shuttles in Bioinspired H2 Production Electrocatalysts.

Although the redox active {Fe(NO)}7 moiety can accept and store an electron and subsequently a proton (forming the relatively unstable Fe-bound HNO), it cannot form a hydride as the

Roles of chemical signals in regulation of the adaptive responses to iron deficiency

Recent studies revealed that chemical compounds, including sucrose, auxin, ethylene and

, positively regulated the Fe-deficiency-induced 

 uptake processes in a cooperative manner.

Formation of glutathionyl dinitrosyl iron complexes protects against iron genotoxicity.

Iron, lanthanum and manganese oxides loaded on gamma-AI2O3 for selective catalytic reduction of NO with NH3 at low temperature.

 conversion and the resistance to H2O and SO2.

Preparation of the elusive [(por)Fe(NO)(O-ligand)] complex by diffusion of nitric oxide into a crystal of the precursor.

 in heme catalases can result in reversible inhibition of enzyme activity, and the Cat(NO) and Cat(NO) compounds have been reported previously.

Exposure to nitric oxide increases the nitrosyl-iron complexes content in sorghum embryonic axes.

The data reported suggest a critical role for the generation of complexes between

 when cells faced a situation leading to a significant increase in NO content.

Nitrosylation in a crystal: remarkable movements of iron porphyrins upon binding of nitric oxide.

For example, it is known that the vasodilator nitric oxide 

) can inhibit the function of heme catalase presumably by direct binding of NO to 

; the Cat(NO) compound has been reported, as has the Cat(NO) derivative.

Peptide-bound dinitrosyliron complexes (DNICs) and neutral/reduced-form Roussin's red esters (RREs/rRREs): understanding nitrosylation of [Fe-S] clusters leading to the formation of DNICs and RREs using a de novo design strategy.

 of [Fe-S] proteins generating protein-bound RREs, reduced protein-bound RREs, or protein-bound DNICs are modulated by both the oxidation state of 

 and the chelating effect of the bound proteins of [Fe-S] clusters.

The unusual electronic structure of dinitrosyl iron complexes.

A salient feature of this electronic structure description is the very covalent bonding involving the

Ferric and ferrous iron in nitroso-myoglobin: computer simulations of stable and metastable States and their infrared spectra.

 is involved in the biological function of many heme proteins.

Nitric oxide accumulation is required for molecular and physiological responses to iron deficiency in tomato roots.

 prevented iron-deficiency-induced upregulation of the basic helix-loop-helix transcription factor 

, the ferric-chelate reductase LeFRO1 and the Fe(II) transporter LeIRT1 genes.

NO binding to naphthalene dioxygenase

While NO is a good oxygen analogue with many similarities to O2, the different binding mode of

 leads to different mechanistic implications.

Iron catalyzed conversion of NO into nitrosonium (NO+) and nitroxyl (HNO/NO-) species.

Results described here contribute to the understanding of the role of

 into HNO/NO- and point to the role of uric acid not previously described.

Oxygen binding to sulfur in nitrosylated iron--thiolate complexes: relevance to the Fe-containing nitrile hydratases.

 promotes sulfur oxygenation of iron dithiolates by dioxygen and stabilizes the S-bonded sulfinate iron species.

Electron paramagnetic resonance for quantitation of nitric oxide in aqueous solutions.

Nitric oxide and cytochrome oxidase: substrate, inhibitor or effector?

At high substrate (ferrocytochrome c) concentrations,

NO sensing by FNR: regulation of the Escherichia coli NO‐detoxifying flavohaemoglobin, Hmp

–S cluster of purified FNR, generating spectral changes consistent with formation of a dinitrosyl‐iron–cysteine complex.

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Possible Interaction: Nitric Oxide and Iron, Dietary

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Research Papers that Mention the Interaction