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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Nitric Oxide and Hesperetin

supplement:

Hesperetin

Research Papers that Mention the Interaction

Hesperetin , but not naringenin, increased NO releases from human umbilical vein endothelial cells in a dose-dependent manner.
Journal of agricultural and food chemistry  •  2008  |  View Paper
We found that hesperetin strongly inhibited nitric oxide production and expression of inducible nitric oxide synthase in LPS-stimulated BV-2 microglial cells.
Archives of pharmacal research  •  2019  |  View Paper
The … hesperetin metabolites (1-10 μM) within … to hesperetin, significantly inhibited nitric oxide (NO) and prostaglandin E(2) (PGE(2)) production, as evidenced by the inhibition of their precursors, inducible nitric … (COX-2) protein levels without appreciable cytotoxicity on LPS-activated RAW264.7 macrophages or A7r5 smooth muscle cells.
Journal of agricultural and food chemistry  •  2012  |  View Paper
Hesperetin also effectively inhibited proinflammatory cytokines, intracellular ROS, and NO in irradiated splenocytes.
Food Science and Biotechnology  •  2016  |  View Paper