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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Nitric Oxide
supplement:
Heme Iron
Research Papers that Mention the Interaction
“The binding of NO to the iron heme in guanylate cyclase and other heme proteins induces the cleavage of the proximal histidine bonded to the metal.”
Modulation of the NO trans effect in heme proteins: implications for the activation of soluble guanylate cyclase“Taken together, our results show that NO can bind to both ferric and ferrous NOS and may inhibit NO synthesis through its binding to the heme iron during catalysis.”
Heme coordination of NO in NO synthase.“Therefore, the oxidation state of heme iron appears to be one important determinant for the inhibitory action of NO , and tetrahydrobiopterin may increase NO synthase activity by diminishing the inhibitory action of NO.”
“Unexpectedly, NO binding to FeB is kinetically favored … prior to the binding of a second NO … heme iron , leading to a (six-coordinate low-spin heme-nitrosyl/FeB-nitrosyl) transient dinitrosyl complex with characteristic …(FeNO)heme at 570 ± 2 cm–1 and ν(NO)FeB at 1755 cm–1.”
The Production of Nitrous Oxide by the Heme/Nonheme Diiron Center of Engineered Myoglobins (FeBMbs) Proceeds through a trans-Iron-Nitrosyl Dimer“Binding of NO to the heme iron of the NT-HBD of HRI activates its eIF2alpha kinase activity, thus inhibiting the initiation of translation in reticulocyte lysate.”
“This suggests a delicate balance between five- and six-coordinate heme iron in both NO and CO complexes.”
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