Possible Interaction: Nitric Oxide and Glabridin

“We observed that Glab significantly suppressed the levels of nitric oxide (NO), NF‐&kgr;B subunit p65, interleukin (IL)‐6, and IL‐1&bgr; in lipopolysaccharide (LPS)‐stimulated HaCaT cells.”

“Increased levels of H2O2 and NO were observed in a dose-dependent manner after treatment of glabridin that further affected macromolecules such as DNA, lipids, and proteins.”

“The levels of SPA, MDA and NO in lung were down-regulated significantly in groups administrated with GLA.”

“Additionally, the nitric oxide level significantly increased upon glabridin pretreatment.”

“ Glabridin showed significant inhibition of NO and IL-1 beta release, but failed to attenuate IL-6 levels at the tested concentrations.”

“Collectively, these data suggest that glabridin inhibits NO production and iNOS gene expression by blocking NF-κB/Rel activation and that this effect was mediated, at least in part, by inhibiting reactive oxygen species generation.”

“ Glabridin attenuated lipopolysaccharide (LPS)-induced NO production in isolated mouse peritoneal macrophages and RAW 264.7 cells, a mouse macrophage-like cell line.”

“In the present study, we report the inhibitory effect of glabridin on nitric oxide (NO) production and inducible nitric oxide (iNOS) gene expression in murine macrophages.”

“Moreover, glabridin (50microM) decreased the 10(-10)M TNF-alpha-induced production of PGE2 and NO in osteoblasts.”