Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: a month ago

Possible Interaction: Nitric Oxide and Ginkgo Biloba Whole

Research Papers that Mention the Interaction

One hypothesis is that ginkgo alters nitric oxide (NO) metabolism, possibly by scavenging NO or altering nitric oxide synthase expression and thereby lessening the vasodilatory effects of NO.
High altitude medicine & biology  •  2004  |  View Paper
Although EGb has been shown recently to inhibit NO production in macrophages, its effect on NO production in endothelial cells is largely unknown.
EGb (50 microg/mL) caused a 30% reduction of NO metabolites released by endothelial cells.
EGb inhibited NO production by attenuating the level of iNOS mRNA in ECV304 cells.
Biochemical pharmacology  •  1999  |  View Paper
Ginkgo biloba extract had a tendency to down-regulate NO bioavailability compared with the AP group, but without statistical significance.
Przeglad gastroenterologiczny  •  2014  |  View Paper
(…GBE … NO was significantly higher than that of the control group [(8.01 ± 0.24, 12.11 ± 0.78, 14.72 ± 0.70 vs 5.83 ± … control group (0.59 ± 0.20, 0.86 ± 0.02, 1.09 ± 0.13 vs 0.41 ± 0.16, all P < 0.05).
CONCLUSION GBE can improve vascular flexibility through increasing the expression of eNOS and the release of NO , protecting the functions of blood vessels.
CONCLUSION GBE can improve vascular flexibility through increasing the expression of eNOS and the release of NO , protecting the functions of blood vessels.
GBE … NO was significantly higher than that of the control group [(8.01 ± 0.24, 12.11 ± 0.78, 14.72 ± 0.70 vs 5.83 ± … control group (0.59 ± 0.20, 0.86 ± 0.02, 1.09 ± 0.13 vs 0.41 ± 0.16, all P < 0.05).
Zhonghua yi xue za zhi  •  2011  |  View Paper
GBE mediated the liver protective effect at least in part by suppressing overproduction of ET-1 and NO and restoring a proper balance between ET-1 and NO to some extent.
Bosnian journal of basic medical sciences  •  2011  |  View Paper
(3) In acute irritation test, the levels of NO in 80%TCE group (60.362 +/- 9.817 micromol/mg pro) and 100%TCE … different compared with blank control group and solvent control group, (P < 0.05 or P < 0.01); In the protection group, 1% GbE , 10% … of NO, ….
3) In acute irritation test, the levels of NO in 80%TCE group (60.362 +/- 9.817 micromol/mg pro) and 100%TCE … different compared with blank control group and solvent control group, (P < 0.05 or P < 0.01); In the protection group, 1% GbE , 10% … of NO, ….
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases  •  2009  |  View Paper
CONCLUSION GBPR has obvious inhibitory effect against the neurotoxicity of NO probably by producing an anti-oxiditive effect through decreasing nNOS synthesis in the brain.
Nan fang yi ke da xue xue bao = Journal of Southern Medical University  •  2009  |  View Paper
Our data indicate that GBB is a more potent inhibitor of NO and PGE2 production than EGb 761, and it also significantly decreased tumor necrosis factor (TNF)-alpha release.
Biological & pharmaceutical bulletin  •  2006  |  View Paper
RESULT The levels of NO in retina in experiment groups were significantly increased compared with controls, after treatment with high dosage of EGB , and levels of NO was decreased to normal.
RESULT The levels of NO in retina in experiment groups were significantly increased compared with controls, after treatment with high dosage of EGB , and levels of NO was decreased to normal.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica  •  2003  |  View Paper
In addition, the GbE treatment markedly decreased the levels of MDA and NO in the tissues of rats (P<0.01).
In addition, the GbE treatment markedly decreased the levels of MDA and NO in the tissues of rats (P<0.01).
Acta pharmacologica Sinica  •  2003  |  View Paper
Show More