Possible Interaction: Nitric Oxide and Ginkgo Biloba Whole

“… GBE … NO was significantly higher than that of the control group [(8.01 ± 0.24, 12.11 ± 0.78, 14.72 ± 0.70 vs 5.83 ± … control group (0.59 ± 0.20, 0.86 ± 0.02, 1.09 ± 0.13 vs 0.41 ± 0.16, all P < 0.05).”

“Although EGb has been shown recently to inhibit NO production in macrophages, its effect on NO production in endothelial cells is largely unknown.”

“ EGb (50 microg/mL) caused a 30% reduction of NO metabolites released by endothelial cells.”

“ EGb inhibited NO production by attenuating the level of iNOS mRNA in ECV304 cells.”

“ GBE administration significantly decreased the reactive oxygen species, lipid peroxidation, nitric oxide , and citrulline levels in comparison to Al-treated rats.”

“ GBE mediated the liver protective effect at least in part by suppressing overproduction of ET-1 and NO and restoring a proper balance between ET-1 and NO to some extent.”

“3) In acute irritation test, the levels of NO in 80%TCE group (60.362 +/- 9.817 micromol/mg pro) and 100%TCE … different compared with blank control group and solvent control group, (P < 0.05 or P < 0.01); In the protection group, 1% GbE , 10% … of NO, ….”

“RESULTS GB tr eatment in vivo decreased the concentrations of protein and NO in the aqueous humor of EIU rats.”

“Here we show that pre-treatment with Ginkgo biloba extract (EGb 761) suppresses the in vivo production of NO (measured by the Griess reaction) after challenge with LPS.”

“ Ginkgo biloba extract had a tendency to down-regulate NO bioavailability compared with the AP group, but without statistical significance.”