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Last Updated: 2 years ago

Possible Interaction: Nitric Oxide and Genistein

supplement:

Genistein

Research Papers that Mention the Interaction

GEN down-regulated CD163 and p-STAT3 expression of THP-…, increased the levels of IL-12 and nitric oxide ( NO ) in the conditioned medium, and reduced the clonogenic and sphere-forming capacities and the expression … by co-culture of THP-1 macrophages and OCSLCs in a dose-dependent manner.
Journal of experimental & clinical cancer research : CR  •  2019  |  View Paper
Pretreatment with NAC, GEN , or both significantly improved ulcer indices and increased nitric oxide level and superoxide dismutase activity.
Canadian journal of physiology and pharmacology  •  2018  |  View Paper
Genistein inhibited insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and attenuated downstream Akt and endothelial nitric oxide synthase (eNOS) phosphorylation, leading to a decreased nitric oxide ( NO ) production in endothelial cells.
The Journal of nutritional biochemistry  •  2013  |  View Paper
Genistein rapidly activates endothelial nitric oxide synthase and production of nitric oxide in ECs.
Current medicinal chemistry  •  2007  |  View Paper
Furthermore, genistein in postmenopausal women increases plasma nitric oxide breakdown products, reduces endothelin-1 levels and improves endothelial dependent vasodilation in post-menopausal women.
Current medicinal chemistry. Cardiovascular and hematological agents  •  2004  |  View Paper
The tyrosine kinase antagonists tyrphostin and genistein inhibited the release of NO by parasite extracts and by GPI, alone or in combination with IFN-gamma, demonstrating the involvement of one or more tyrosine kinases in the signaling cascade.
Journal of immunology  •  1996  |  View Paper
Genistein , a tyrosine kinase inhibitor, resulted in a profound suppression of the IGF-I-induced release of NO.
Kidney international  •  1994  |  View Paper
Our data indicate that the LPS-stimulated increases in COX-2 protein level and NO in supernatant are reduced by pretreatment of genistein , whereas COX-1 protein level is not affected by genistein.
The Journal of nutritional biochemistry  •  2007  |  View Paper
We also found that pretreatment with three flavonoids, including quercetin, genistein , and luteolin, blocked nitric oxide synthesis in a dose-dependent fashion.
European journal of pharmacology  •  2006  |  View Paper
RESULTS With ge istein in creasing, the activities of GSH-Px, NOS and the contents of NO in creased significantly (P < 0.05), while the contents of GSH, MDA decreased both in culture supernatant and cells (P < 0.05).
Wei sheng yan jiu = Journal of hygiene research  •  2004  |  View Paper
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