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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nitric Oxide
supplement:
Ferrous
Research Papers that Mention the Interaction
“Reactions at ferrous and ferric heme sites have differing consequences and affinities for interactions with NO.”
Critical redox and allosteric aspects of nitric oxide interactions with hemoglobin.“The one thousand times higher affinity of ferrous heme for nitric oxide , a potent vasodilator of cerebral vessels, than to oxygen, has led to the concept that hemoglobin scavenges nitric oxide and produces delayed cerebral vasospasm after SAH.”
“Our results show that in the ferrous proteins NO exhibits a considerable trans effect.”
“Furthermore, NO and H2S interact with ferrous and ferric heme iron, respectively, which affects the activity of central heme proteins.”
Exploring pathways of NO and H2S signaling in metabolic depression: The case of anoxic turtles.“These characteristics, so far not observed in other hemoproteins, indicate that NO encounters a high energy barrier for escaping from the heme pocket once the His–Fe2+ bond has been cleaved; this bond does not reform before NO recombination.”
“The measurement of nitric oxide concentration in biological systems is a challenging analytic problem because nitric oxide is also rapidly inactivated by Fe(II) , Fe(III), and O2, all of which are found in great abundance in biological systems.”
“Taken together, our results show that NO can bind to both ferric and ferrous NOS and may inhibit NO synthesis through its binding to the heme iron during catalysis.”
“ NO binding to both ferrous and ferric centers involves the lowering of their spin states.”
“ NO binding to ferrous hemes of the form (por)Fe(L) (L = neutral N-based ligand) to give the {FeNO}7 (por)Fe(NO)(L) product results in a lengthening of the axial trans Fe–L bond.”
Insights into the Observed trans-Bond Length Variations upon NO Binding to Ferric and Ferrous Porphyrins with Neutral Axial Ligands“Here, we report that the ferrous ions in Fe(2+)-exchanged MOF-5 disproportionate nitric oxide to produce nitrous oxide and a ferric nitrito complex.”
“ Ferrous and ferric Mt-… high reactivity towards NO ; however, the conversion of nitrite to NO is facilitated primarily by ferrous Mt-trHbN. Values of kinetic and/or thermodynamic parameters … the ligand diffusion pathways to/from the heme, the heme distal pocket structure and polarity, and the ligand stabilization mechanisms.”
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