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Possible Interaction: Nitric Oxide and Ferrous

supplement:

Ferrous

Research Papers that Mention the Interaction

Reactions at ferrous and ferric heme sites have differing consequences and affinities for interactions with NO.
Antioxidants & redox signaling  •  2004  |  View Paper
The one thousand times higher affinity of ferrous heme for nitric oxide , a potent vasodilator of cerebral vessels, than to oxygen, has led to the concept that hemoglobin scavenges nitric oxide and produces delayed cerebral vasospasm after SAH.
Acta neurochirurgica. Supplement  •  2001  |  View Paper
Our results show that in the ferrous proteins NO exhibits a considerable trans effect.
JBIC Journal of Biological Inorganic Chemistry  •  2005  |  View Paper
These characteristics, so far not observed in other hemoproteins, indicate that NO encounters a high energy barrier for escaping from the heme pocket once the His–Fe2+ bond has been cleaved; this bond does not reform before NO recombination.
The Journal of Biological Chemistry  •  2001  |  View Paper
The measurement of nitric oxide concentration in biological systems is a challenging analytic problem because nitric oxide is also rapidly inactivated by Fe(II) , Fe(III), and O2, all of which are found in great abundance in biological systems.
Hypertension  •  1996  |  View Paper
Taken together, our results show that NO can bind to both ferric and ferrous NOS and may inhibit NO synthesis through its binding to the heme iron during catalysis.
Proceedings of the National Academy of Sciences of the United States of America  •  1994  |  View Paper
Furthermore, NO and H2S interact with ferrous and ferric heme iron, respectively, which affects the activity of central heme proteins.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology  •  2020  |  View Paper
Here, we report that the ferrous ions in Fe(2+)-exchanged MOF-5 disproportionate nitric oxide to produce nitrous oxide and a ferric nitrito complex.
Journal of the American Chemical Society  •  2015  |  View Paper
Ferrous and ferric Mt-… high reactivity towards NO ; however, the conversion of nitrite to NO is facilitated primarily by ferrous Mt-trHbN. Values of kinetic and/or thermodynamic parameters … the ligand diffusion pathways to/from the heme, the heme distal pocket structure and polarity, and the ligand stabilization mechanisms.
PloS one  •  2014  |  View Paper
Nitric oxide was further chemically reduced by ferrous iron to nitrous oxide.
Archives of Microbiology  •  2004  |  View Paper
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