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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nitric Oxide
supplement:
Ferric Ion
Research Papers that Mention the Interaction
“ NO , therefore, is a weak ligand to ferric heme , which, at the same time, forms a strong Fe-NO bond.”
Electronic structure of heme-nitrosyls and its significance for nitric oxide reactivity, sensing, transport, and toxicity in biological systems.“ Ferric CLOCK PAS-A undergoes reductive nitrosylation in the presence of NO to generate a CLOCK PAS-A-NO, which is a five-coordinate {FeNO}(7) complex.”
“ NO thus binds 500-fold more tightly to ferric hHO-1-heme than to met-Mb.”
“The results are consistent with the hypothesis that the nitrosating agent is the NO(+) species, which is generated during the NO driven reduction of the ferric heme iron.”
“Unlike carbon monoxide or oxygen, NO can also bind reversibly to ferric iron.”
“The first step in the reaction of NO with the ferric heme is the reversible formation of the formally iron(III) adduct.”
“All three gases — NO , NO2, and O3 — significantly increase the signal due to high-spin ( S = 5 2 ) ferric catalase , while NO, NO2, and O3 all depress the level of iron transferrin.”
“The slower GR of NO to Hb(III) may be caused by the lower reactivity of NO to the heme Fe(iii).”
“The quantification of intracellular iron levels in leukemia cells indicated that NO induced an early, dose-dependent decrease in ferric iron levels.”
“ NO binds to both ferric (Fe(III) , the catalytically active species) and ferrous (Fe(II)) forms of MPO, generating stable low-spin six-coordinate complexes, MPO-Fe(III).NO and MPO-Fe(II).NO, respectively.”
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