Possible Interaction: Nitric Oxide and Ebselen

“Similarly, pretreating cells with the potent H2O2 scavenger ebselen significantly reduced the production of H2O2, O2 – and NO compared with BCG alone, highlighting the importance of H2O2 generation in this system.”

“In agreement with this fact, ebselen , a GSH peroxidase mimic, abrogated the increase in NO toxicity induced by H2O2.”

“The … ebselen reduced sciatic nerve damage …), levels of MDA, NO , and inducible nitric oxide synthase (iNOS) positive cells (p<0.01, p<0.05, respectively), and increased SOD, GPx, and ….001, p<0.01, p<0.05, respectively) compared with the I/R group that did not receive ebselen.”

“Moreover, ebselen significantly reduced the NO and iNOS mRNA levels and inhibited TLR4 and p‐p38 MAPK expression, indicating the involvement of NO and p38 MAPK signalling pathways in the neuroprotection afforded by ebselen.”

“Together, these findings suggest that ebselen protects neuronal cells from NO cytotoxicity by reciprocally regulating the apoptotic and antiapoptotic signaling cascades.”

“In precontracted rat …, relaxations induced by NO donors, electrical field stimulation and 5-[1-(phenylmethyl)-1H-…-yl]-2-furanmethanol (YC-1) were significantly inhibited by ebselen (100 microM), whereas responses elicited by papaverine and theophylline were not affected; … 8-bromo-cyclic-guanosine-monophosphate (8-Br-cGMP) were slightly enhanced.”

“These results suggest that ebselen exerts an inhibitory action on the nitric oxide synthesis in rat thoracic aorta by interacting with thiol groups.”