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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nitric Oxide
supplement:
Diallyl Disulfide
Research Papers that Mention the Interaction
“We found that pretreatment with DADS prior to treatment with LPS significantly inhibited excessive production of nitric oxide ( NO ) and prostaglandin E₂ (PGE₂) in a dose-dependent manner.”
Inhibitory effects of diallyl disulfide on the production of inflammatory mediators and cytokines in lipopolysaccharide-activated BV2 microglia.“ DADS decreased nitric oxide production with a reduction in the levels of interleukins (IL)-1β and IL-6 in RAW264.7 cells stimulated with LPS.”
Diallyl-disulfide, an organosulfur compound of garlic, attenuates airway inflammation via activation of the Nrf-2/HO-1 pathway and NF-kappaB suppression.“ DADS inhibited activated NO production by decreasing inducible NO synthase expression and by directly clearing NO, whereas AMS suppressed NO mainly through its direct NO clearance activity.”
“ Diallyl disulfide , allyl, phenyl, and benzyl isothiocyanates inhibited NO production, as evaluated by nitrite formation at 25 microM. Allyl and benzyl isothiocyanates, the most active of the six organosulfur compounds, exhibited dose-dependent inhibition and had IC(50) values of 1.6 and 2.7 microM, respectively.”
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