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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Nitric Oxide
supplement:
D-Serine
Research Papers that Mention the Interaction
“Suppression of NO production by d-serine in U87 cells contrasts its known action in enhancing nNOS in neurons.”
“Thus, the metabolism of both d-serine and NO in U87 cells is functionally correlated in a complex manner.”
Mutual regulation between serine and nitric oxide metabolism in human glioblastoma cells“Collectively, we show that spinal D-serine modulates nNOS activity and concomitant NO production leading to increases in PKC-dependent pGluN1 and ultimately contributing to the induction of mechanical allodynia following peripheral nerve injury.”
“In naïve mice, exogenous D-serine increased NO levels via decreases in pnNOS.”
Astrocyte D-serine modulates the activation of neuronal NOS leading to the development of mechanical allodynia in peripheral neuropathy“ D-serine released from astrocytes induces a rapid increase in NO contents in postsynaptic neurons.”
“Overall, D-serine production in astrocytes is negatively regulated by NO.”
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