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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Nitric Oxide
supplement:
D-Arginine
Research Papers that Mention the Interaction
“ d-arginine also activated NO production and could be inhibited by imidazoline and α-2 AR antagonists, thus indicating nonsubstrate actions of arginine.”
Receptor-mediated activation of nitric oxide synthesis by arginine in endothelial cells“It was also observed that high doses of either L-arginine or D-arginine inhibit NO production.”
“Subsequently, these data show that L-arginine and D-arginine are involved in a mechanism that inhibits NO production.”
Opposite effects of low and high doses of arginine on glutamate-induced nitric oxide formation in rat substantia nigra“The use of pharmacological agents … of nitric oxide), D-arginine (non-precursor of nitric oxide) N(omega_-nitro-L-arginine and N(omega)-nitro-L-…-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (nitric oxide scavenger), demonstrated that nitric oxide modulated this depression phenomenon …. facilitation or inhibition.”
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