Possible Interaction: Nitric Oxide and Cyanidin

“In the present …, we identified that cyanidin treatment could strongly suppress the expression of NO , PGE2, TNF-α, IL-6, iNOs, COX-2, ADAMTS5 and MMP13, and reduce the degradation of aggrecan and collagen II in IL-1β-induced human OA chondrocytes, indicating the anti-inflammatory effect of cyanidin.”

“Similarly, both C3G and Cy suppressed nitric oxide production and inflammatory cytokines secretion of LPS-induced Caco-2 cells.”

“SK-N-SH … h. Pretreatment with cyanidin (20 μmol/L) or NAC (20 μmol/L) strongly inhibited the NF-κB signaling pathway in the cells evidenced by suppressing … NF-κB from the cytoplasm to the nucleus, and thereby reducing the expression of iNOS protein and the production of NO.”

“Phenolic compounds at the range of 16-500 microM that inhibited NO production by > 50% without showing cytotoxicity were the flavonols quercetin and myricetin, the isoflavone daidzein, and the anthocyanins/anthocyanidins pelargonidin, cyanidin , delphinidin, peonidin, malvidin, malvidin 3-glucoside, and malvidin 3,5-diglucosides.”

“spectroscopy studies with Fe2+‐diethyldithiocarbamate as an NO spin trap demonstrated that RWPC and leucocyanidol increased NO levels in rat thoracic aorta about 2 fold.”