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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Nitric Oxide
supplement:
Cuprous
Research Papers that Mention the Interaction
“Recently, we have shown that copper Cu(I) ) inhibits the release of NO in lipopolysaccharide (LPS)-stimulated BV2 microglia and induces BV2 microglia to acquire a mixed a profile with both pro- and anti-inflammatory characteristics.”
“These data provide direct evidence that Cu(I) disrupts S-nitrosothiol homeostasis and NO metabolism, and, thus, provide new insights into the mechanisms involved in microglia-mediated-CNS disorders.”
Copper disrupts S-nitrosothiol signaling in activated BV2 microglia“In the present study we show that Cu(I) modulates the release of NO to the media, without altering iNOS expression, and produces phenotypic changes in BV2 microglia.”
“This effect is Cu(I)-specific and it is not observed with other non-redox metals, suggesting that Cu(I) modulates NO reactivity.”
“The … NO … Cu+B and Fe2+a3 of cytochrome c oxidase can contribute to NO cytotoxicity and to the catalysis of NO reduction to N2O and makes … the effective use of infrared spectroscopy in investigations of Cu as well as Fe at the binuclear O2 reduction sites of oxidases.”
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