Possible Interaction: Nitric Oxide and Cupric Cation

“2 Cu2+ (10−6–10−4 m) significantly increased NO production in a dose‐dependent manner when extracellular Ca2+ was present.”

“ NO and NO-donors are able to inhibit the peroxidation of polyunsaturated fatty acids in human low-density lipoproteins (LDL) exposed to Cu+2.”

“Here we report that two donors (NOC-9 and NOC-18) with different half times of NO release (2.7 and >500 min, respectively) inhibit in vitro lipoprotein oxidation promoted by Cu++.”

“These results clearly indicate that NO inhibits the oxidative modification of LDL induced by Cu2+.”

“The Cu(II) complexes of these fluorescent probes react with NO under anaerobic conditions to yield a 20-45-fold increase in integrated emission.”

“With this system, we have now demonstrated that EDRF is protected from breakdown by superoxide dismutase (SOD) and Cu2+ , but not by catalase, and is inactivated by Fe2+.”

“The [Cu(hfac)(Nit-Ph-PyIm)]+ unit is diamagnetic owing to the strong antiferromagnetic coupling between the Cu(ii) ion and the equatorially coordinated NO group.”

“The base-catalyzed reaction of nitric oxide with the Cu(II) complex Cu(DAC)2+ (DAC = 1,8-bis(9-anthracyl-methyl)-(1,4,8,11-tetraazacyclotetradecane)) leads to reduction of the metal center and the unexpected intramolecular nitrosylation of a secondary amine.”

“The strong oxidant Cu2+ , even in the presence of air oxygen, accelerated oxidation and increased · NO release from SIN-1 up to 86%.”

“On the other hand, NO dose-dependently inhibited the strand breakage mediated by 1,4-hydroquinone plus Cu2+ or Fenton reaction (H2O2, iron or copper).”