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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nitric Oxide
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Conclusions— Our results identify a novel mechanism by which NO can increase the efficacy of calcium , rising vasoactive agonists in the microvascular endothelium.”
“Functionally, the inhibition of gap junctional intercellular communication by NO decreased the spread of the calcium signal (induced by mechanical stimulation of individual endothelial cells) from endothelial to smooth muscle cells in intact vessels, while, at the same time, augmenting the calcium signal spreading within the endothelium.”
“However, they are emerging as agents with diverse roles in modulating the dynamics of intracellular calcium and the generation of reactive oxygen species and nitric oxide.”
“The calcium increase mediated by NMDA receptor activation is thus associated with nitric oxide generation , and the combination leads to the collapse of mitochondrial membrane potential followed by cell death.”
“ Calcium can, however, also modulate the activity of enzymes that produce calcium-mobilising metabolites such as IP3, arachidonic acid and nitric oxide.”
“Thus, NO production by endothelial cells is stimulated by factors that increase intracellular calcium concentration including receptor-dependent agonists like acetylcholine, bradykinin, substance P, and … * Corresponding author.”
“The mutual regulation of calcium and NO was also investigated.”
Phorbol myristate acetate induces differentiation of THP-1 cells in a nitric oxide-dependent manner.“ CA also significantly decreased the release of interleukin-6, tumor necrosis factor-α, and nitric oxide from lipopolysaccharide-induced RAW 264.7 cells.”
“This intracellular rise in calcium is responsible for triggering several cellular responses, including the synthesis of nitric oxide , endothelium-derived hyperpolarizing factor, and eicosanoids derived from arachidonic acid.”
“The results show that NO elevates calcium in concentration-dependent manner in HeLa cells.”
“The high dose of calcium in the system activates the nitric oxide synthase, synthesizing nitric oxide which then downregulates Mdm2 and influences drastically the p53-Mdm2 network regulation, lifting the system from a normal to a stressed state.”
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