Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Nitric Oxide and Calcium Supplement

Research Papers that Mention the Interaction

Conclusions— Our results identify a novel mechanism by which NO can increase the efficacy of calcium , rising vasoactive agonists in the microvascular endothelium.
Functionally, the inhibition of gap junctional intercellular communication by NO decreased the spread of the calcium signal (induced by mechanical stimulation of individual endothelial cells) from endothelial to smooth muscle cells in intact vessels, while, at the same time, augmenting the calcium signal spreading within the endothelium.
Arteriosclerosis, thrombosis, and vascular biology  •  2017  |  View Paper
However, they are emerging as agents with diverse roles in modulating the dynamics of intracellular calcium and the generation of reactive oxygen species and nitric oxide.
Circulation research  •  2007  |  View Paper
The calcium increase mediated by NMDA receptor activation is thus associated with nitric oxide generation , and the combination leads to the collapse of mitochondrial membrane potential followed by cell death.
Diabetes  •  2004  |  View Paper
Calcium can, however, also modulate the activity of enzymes that produce calcium-mobilising metabolites such as IP3, arachidonic acid and nitric oxide.
Current Biology  •  2003  |  View Paper
Thus, NO production by endothelial cells is stimulated by factors that increase intracellular calcium concentration including receptor-dependent agonists like acetylcholine, bradykinin, substance P, and … * Corresponding author.
Cardiovascular research  •  2000  |  View Paper
The results show that NO elevates calcium in concentration-dependent manner in HeLa cells.
Scanning  •  2014  |  View Paper
The high dose of calcium in the system activates the nitric oxide synthase, synthesizing nitric oxide which then downregulates Mdm2 and influences drastically the p53-Mdm2 network regulation, lifting the system from a normal to a stressed state.
Molecular bioSystems  •  2013  |  View Paper
Calcium entry leads to the activation of nitric oxide (NO) synthetase causing NO synthesis.
Internal and emergency medicine  •  2011  |  View Paper
In conclusion, the simultaneous determination of IL-18 or NO in combination with the CA 15.3 may increase the sensitivity to diagnose breast cancer and may aid in disease prognosis.
Medical oncology  •  2011  |  View Paper
Deficiency of substrate (arginine), cofactor (tetrahydrobiopterin, BH4) and calcium can decrease the NO synthesis.
Orvosi hetilap  •  2010  |  View Paper
Show More