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Last Updated: 3 years ago

Possible Interaction: Nitric Oxide and Caffeic Acid

supplement:

Caffeic Acid

Research Papers that Mention the Interaction

Furthermore, THCA downregulated the levels of inducible nitric oxide (iNOS), cyclooxygenase-2 (COX-2), and leukotriene B4 (LTB4) expression, mucus production and CREB phosphorylation as well as Penh value.
International immunopharmacology  •  2020  |  View Paper
CA was found to diminish nitric oxide (NO) and prostaglandin E2 (PGE2) production in LPS-stimulated RAW264.7 cells.
Mediators of inflammation  •  2013  |  View Paper
Among them, the compounds that most effectively inhibited lipopolysaccharide-induced NO production were caffeic acid and methylchlorogenic acid, with IC50 values of 7 μg/mL and 12 μg/mL, respectively.
Journal of enzyme inhibition and medicinal chemistry  •  2010  |  View Paper
Incubation with CA also led to significantly decreased levels of malondialdehyde, nitric oxide , acetylcholinesterase, butyrylcholinesterase, and ATPase activities.
Journal of biochemical and molecular toxicology  •  2020  |  View Paper
Moreover, CA reduced the percentage of infected macrophages and the number of amastigotes per macrophages increasing TNF-α, ROS, NO and reducing IL-10 levels as well as iron availability.
Phytomedicine : international journal of phytotherapy and phytopharmacology  •  2019  |  View Paper
Only caffeic acid significantly increased nitric oxide production by infected macrophages.
Journal of enzyme inhibition and medicinal chemistry  •  2019  |  View Paper
Furthermore, CAFF suppressed caspase‐3 and inducible nitric oxide synthase expressions.
Journal of biochemical and molecular toxicology  •  2018  |  View Paper
Among the metabolites, caffeic acid and 3,4-dihydroxyphenylacetic acid showed the strongest inhibitory effects on NO production in both cell lines, without having cytotoxic effect.
International journal of molecular sciences  •  2017  |  View Paper
Propolis and caffeic acid inhibited NO production in macrophages, at concentrations without cytotoxicity.
The concentrations … and caffeic acid that … NO production were evaluated on intracellular signaling pathways triggered during inflammation, namely p38 mitogen-activated protein kinase (MAPK), c-jun NH2-terminal … (JNK1/2), the transcription nuclear factor (NF)-κB and extracellular signal-regulated kinase (ERK1/2), through Western blot using specific antibodies.
Journal of ethnopharmacology  •  2013  |  View Paper
Caffeic acid pre-intake at test doses and post-intake at 2% declined the expression of iNOS, COX-2 and GFAP; and lowered the production of NO and PGE₂ (P < 0.05).
European journal of pharmacology  •  2011  |  View Paper
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