“Bergenin treatment was initiated after LPS stimulation for 24 h. The results indicated that bergenin attenuated inflammatory cell infiltration and decreased the concentration of NO , TNF-α, IL-1β, and IL-6, which were increased in LPS-induced mouse mastitis.”
“In conclusion, bergenin reduced the expression of NO , TNF-α, IL-1β, and IL-6 proinflammatory cytokines by inhibiting the activation of the NF-κB and MAPKs signaling pathways, and it may represent a novel treatment strategy for mastitis.”