Possible Interaction: Nitric Oxide and Asymmetric Dimethylarginine

“The correlation between the decrease of ADMA and increase of NO subsequent to weight loss was significant (P < 0.0001).”

“Elevated plasma levels of asymmetric dimethylarginine ( ADMA) inhibit nitric oxide formation and exert a proatherogenic action.”

“Moreover, ADMA , l‐NMMA and l‐leucine were effective inhibitors of NO synthesis in both hypertensive and control platelets.”

“To the … inhibitor of nitric oxide (NO) synthase3,4 that has been recently associated independently with increased cardiovascular event rates.5 Nocturnal hemodialysis (NHD) (5 to 6 … glyceryl trinitrate (GTN) is enhanced.7 ADMA inhibits competitively all 3 isoforms of NO synthase.8 When infused into healthy humans, ADMA …”

“Infusion of ADMA caused a significant decrease in plasma cyclic guanosine monophosphate (cGMP) levels, i.e. the second messenger of NO (from 6.1 ± 0.4 to 4.3 ± 0.3 pmol/l; p < 0.05).”

“In addition, significant negative correlations were detected between the plasma concentration of nitric oxide and the plasma concentration of homocysteine (r=-0.592, P<0.0001) and ADMA (r=-0.789, P<0.0001).”

“As NO synthesis can be antagonized by its endogenous inhibitor asymmetric dimethyl L-arginine (ADMA), we determined ADMA plasma concentrations, which were elevated at baseline in comparison to healthy middle-aged individuals (3.9 6 0.2 versus 1.0 6 0.1 mmol/l; p, 0.0001).”

“ ADMA is a potent inhibitor of NO synthesis, and accumulates in the plasma of patients with renal failure.”

“Although asymmetrical dimethyl arginine , an inhibitor of nitric oxide , has been shown to be associated with progression of renal disease, symmetric dimethyl arginine may be a better marker.”

“Moreover, ADMA reduced the NO concentration in PT1001B‐treated HK2 cells.”