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Possible Interaction: Nitric Oxide and Apigenin



Research Papers that Mention the Interaction

Importantly, apigenin and naringenin significantly increased NO production in endothelial cells subjected to high glucose challenge.
Vascular pharmacology  •  2016  |  View Paper
Apigenin inhibited the collagenase activity involved in rheumatoid arthritis (RA) and suppressed lipopolysaccharide (LPS)-induced nitric oxide ( NO ) production in a dose dependent manner in RAW 264.7 macrophage cells.
Archives of pharmacal research  •  2007  |  View Paper
Apigenin significantly inhibited the LPS-induced expression of iNOS, COX-2, expression of pro-inflammatory cytokines (IL-1β, IL-2, IL-6, IL-8, and TNF-α), and AP-1 proteins (c-Jun, c-Fos, and JunB) including nitric oxide production.
Inflammation  •  2015  |  View Paper
API … nitric oxide (NO), nitric oxide synthase (iNOS) and cytosolic phospholipase A2 (cPLA2), which were induced by the treatment of HepG2 cells with 1 µg/ml … system, and this activation may be responsible for their antiinflammatory effects, as demonstrated by the suppression of LPS‐induced NO, iNOS and cPLA2.
Biopharmaceutics & drug disposition  •  2015  |  View Paper
Also, Choi has documented that treatment with apigenin decreased the TNF-a-induced production of NO in osteoblasts suggesting that apigenin may be a new pharmacological tool for the treatment of osteoporosis.
Angiology  •  2014  |  View Paper
Apigenin significantly inhibited the nicotine- and LPS-induced production of NO , PGE2, IL-1beta, TNF-alpha, IL-6, and IL-12, and the upregulation of iNOS and COX-2 in hPDL cells.
International immunopharmacology  •  2009  |  View Paper
Prevention of all three NO , Ca2+, and KCa signaling) reversed the antiangiogenic effects of Api under both basal and basic fibroblast growth factor‐induced culture conditions.
Journal of thrombosis and haemostasis : JTH  •  2007  |  View Paper
The immunomodulating effects of apigenin were also characterized by a change in the inflammatory profile as evidenced by a significant decrease in interleukin-10 and tumor necrosis factor production and increased nitric oxide levels.
Anti-cancer drugs  •  2016  |  View Paper
Despite the relatively weak anti-diabetic and anti-AD potentials, apigenin showed powerful antiinflammatory activity by inhibiting NO production and iNOS and COX-2 expression while vitexin and isovitexin were inactive.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2014  |  View Paper
Of the compounds that were evaluated, apigenin inhibited the production of nitric oxide and prostaglandin E(2) by suppressing the expression of inducible nitric oxide synthase and cyclooxygenase-2 protein, respectively.
Neurochemistry International  •  2008  |  View Paper
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