Possible Interaction: Nitric Oxide and 3-Nitrotyrosine

“In addition, NO alters many signaling pathways through chemical modifications, such as the addition of S-nitrosothiols and nitrosotyrosine to target proteins altering various biological pathways.”

“This excess of nitric oxide reacts with cellular proteins yielding nitrotyrosine , thus contributing to cerebral damage.”

“Preventing formation of nitrotyrosine by inhibit- ing nitric oxide synthase rescued cultured motor neurons from excitotoxic death induced by adding glutamate to the culture medium, but failed to significantly delay death of motor neurons expressing the G93A mutant SOD1.”

“Also, NO produced markedly less 3-nitrotyosine in SOD1-Tg cells.”

“Treatment with CDDP and NO increased amounts of nitrotyrosine protein adducts , indicative of peroxynitrite formation, and promoted the induction of AKR1B10, inferring a relationship between peroxynitrite formation and the enzyme upregulation in the cells.”

“These results suggest that the free amino acid form of 3-nitrotyrosine can affect the tissue repair process by modulating nitric oxide production.”

“ NO has been shown to modify protein function by nitrosylation and nitrotyrosination , contribute to glutamate excitotoxicity, inhibit mitochondrial respiratory complexes, participate in organelle fragmentation, and mobilize zinc from internal stores.”

“These results demonstrate that the inhibitory effect of NO on collagen-induced platelet aggregation may be mediated by the nitrotyrosylation of the 65-kDa receptor.”

“ NO increases the formation of 3-nitrotyrosine and is accompanied by an increase in levels of 3-chlorotyrosine (a marker of neutrophil activation).”

“Although the role of NO in asthma is unknown, reactive metabolites of NO may lead to nitrotyrosine formation and promote airway dysfunction.”