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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Nitric Oxide and 1-(P-Hydroxybenzyl)-6,7-Dihydroxy-1,2,3,4-Tetrahydroisoquinoline

Research Papers that Mention the Interaction

Higenamine concentration-dependently inhibited NO production and inducible NO synthase mRNA in RAW 264.7 cells, in which the IC(50) was 53 microM. Higenamine (10 mg/kg i.p.)
The Journal of pharmacology and experimental therapeutics  •  1999  |  View Paper
All three forms of higenamine inhibited iNOS expression and reduced NO production with IC50 of 26.2, 86.3, and 53.4 microM, for (S)-, (R)-, and (RS)-higenamine, respectively.
International immunopharmacology  •  2006  |  View Paper
Our data showed that Hig significantly inhibited the production of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), reactive oxygen species (ROS) as well as NO (mediated by iNOS) and PGE2 (mediated by COX2) in LPS-activated BV2 cells.
International immunopharmacology  •  2020  |  View Paper