Possible Interaction: Nisoldipine and Calcium Supplement

“1 μM and total inhibition of primedO2/− response at 1.5 μM. Nisoldipine (1.5 μM) also abolished the incremental rise of Ca++i in primed neutrophils stimulated with FMLP.”

“ Nisoldipine inhibits calcium (Ca++) influx in human neutrophils: Preincubation with the dihydropyridine, nisoldipine (1.5 μM) resulted in a 30% decrease in[45]Ca++ influx during formyl-methionineleucine-phenylalanine (FMLP) stimulation in primed as well as resting cells.”

“The inhibition of the Ca2+ current (ICa) was reduced by nisoldipine (an L‐type Ca2+ channel antagonist) by nearly 50%, and was unaltered by omega‐conotoxin GVIA, a blocker of N‐type Ca2+ channels.”

“ Nisoldipine inhibited the efflux of simultaneously infused calcium.”

“3 Clear cut differences were observed with amiloride, guanethidine, nimodipine and nisoldipine which behaved as selective blockers of DMPP‐mediated Ca uptake responses: IC50 values to block DMPP effects were 290, 27, 1.1 and 1.63 μm respectively for amiloride, guanethidine, nimodipine and nisoldipine.”

“ Nisoldipine inhibited K‐evoked Ca uptake only partially at low concentrations (about 30%); a second blocking component was observed at the highest concentration used (10 μm).”

“The inhibitory effect of nisoldipine on vasoconstrictor responses to neuronally released norepinephrine may be important in the antihypertensive actions of calcium entry blocking agents.”

“5 After prolonged superfusion (over 120 min) with Na‐ and Ca‐free solution (guanethidine and atropine were present), application of 2.6 mm Ca produced contraction which was inhibited by 10−8 m nisoldipine , while the depolarization induced by application of these solutions was not inhibited by nisoldipine.”