supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Nimodipine
supplement:
Potassium
Research Papers that Mention the Interaction
“Both nifedipine and nimodipine effectively inhibited contractions induced by calcium in pial arteries pretreated in a calcium-free medium and depolarised by potassium.”
“In pial arteries the calcium antagonists nifedipine and nimodipine caused an almost complete relaxation of contractions induced by potassium at drug concentrations relaxing prostaglandin F2α-contracted vessels to only about 60%.”
Effects of Extracellular Calcium and of Calcium Antagonists on the Contractile Responses of Isolated Human Pial and Mesenteric Arteries“We suggest that nimodipine suppressed the firing of APs in cultured neonatal rat hippocampal neurons due to inhibition of both calcium and potassium currents.”
Nimodipine inhibits AP firing in cultured hippocampal neurons predominantly due to block of voltage-dependent potassium channels.“In dura mater, blockade of P/Q-, N- and L-type VGCCs by ω-agatoxin TK, ω-conotoxin GVIA and nimodipine at 1 μM respectively, significantly decreased the potassium induced CGRP release.”
“In Fura2-loaded cells, nimodipine strongly antagonized the internal calcium rise due to superfusion with 15-75 mM potassium.”
“The effect of high potassium medium was less pronounced and only slightly inhibited by nimodipine.”
“The increase in potassium during ischemia and Nimodipine (calculated in change of concentration/time [dc/dt]) is significantly slower than in the control group.”
“ Potassium depolarization evoked contraction and rhythmic activity that was blocked by nimodipine (IC50 0.08 nM).”
“At the highest concentration, nifedipine and nimodipine reduced the serotonin and potassium responses to an average of 19|X% and 6|X% of control response.”
“Diltiazem and nimodipine inhibited responses to potassium and acetylcholine without affecting those to norepinephrine.”
“ Nimodipine had no inhibitory effect on the response to norepinephrine but suppressed the responses to potassium and 5-HT.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback