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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nimodipine
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“After 2–3 weeks of nimodipine treatment, CSF Ca ] was significantly lower in the subgroup treated with 60 mg nimodipine four times daily (240 mg/d) than with 30 mg four times daily.”
Cations of Cisternal Cerebrospinal Fluid in Humans and the Effect of Different Doses of Nimodipine on CSF Calcium after Stroke“ Nimodipine is a compound that is thought to block the influx of calcium through channels in vascular smooth muscle.”
“Blocking various mechanisms of intracellular calcium accumulation by simulated pharmacological agents ( nimodipine , IP3- and ryanodine-blockers) reproduced experimentally observed trends in firing rate dynamics and core-clock gene transcription.”
“ Nimodipine modulated the calcium action potential in an ageand concentration‐dependent fashion; concentrations as low as 100 nM reduced the calcium action potential in aging CA1 neurons without effects on young cells. (”
“Regarding its neuronal effects it seems likely that nimodipine potently blocks calcium entry during pathological conditions like cerebral ischaemia and spreading cortical depression.”
“This calcium signal is totally blocked when cells are stimulated in the presence of DHP receptor inhibitors such as nimodipine or calcicludine, thus suggesting the implication of this L-type calcium channel.”
“Nimodipine did not significantly modify … arachidonate metabolites: this suggests that Nimodipine treatment, which definitely improves long‐term results of patients for intracranial aneurysms, could exert its … reducing Ca++ intake from the extracellular compartment and preventing a direct toxic effect of calcium , without a direct action … release of vasoactive compounds.”
“Both nifedipine and nimodipine effectively inhibited contractions induced by calcium in pial arteries pretreated in a calcium-free medium and depolarised by potassium.”
“Here, we found that the L-type Ca2+ channel blocker nimodipine could hyperpolarize the membrane potential, decrease the spontaneous activity, and reduce the intracellular Ca2+ levels in arcuate NPY neurons from Tg2576 brain slices.”
Amyloid-Beta Modulates Low-Threshold Activated Voltage-Gated L-Type Calcium Channels of Arcuate Neuropeptide Y Neurons Leading to Calcium Dysregulation and Hypothalamic Dysfunction“And nimodipine , an antagonist of calcium , could reverse those changes as well.”
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