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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nimodipine
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“Subsequent application of corticotropin in the presence of nimodipine failed to produce an enhancement of I(Ca), suggesting that corticotropin acts selectively on L-type channels.”
Selective enhancement of l-type calcium currents by corticotropin in acutely isolated rat amygdala neurons.“We found that nimodipine markedly inhibited ACTH release at all intervals tested, whereas omega-Agatoxin IVA, omega-Conotoxin MVIIC, and omega-Conotoxin GVIA had no significant effect.”
“Perifusing 0.2 mM nimodipine , a dihydropyridine Ca2+ channel blocker, before and after restoration of Ca2+ to the Ca2(+)-free medium inhibited ACTH release by 40-48%, and the blockade persisted for at least 70 min after nimodipine was removed from the medium.”
“Although treatment with CRF does not alter the concentration of cell-associated calcium in D16 cells, ACTH secretion stimulated by both CRF and elevated medium K+ are inhibited by nimodipine in a dose-related manner.”
“Since glucocorticoids feedback regulates biosynthesis and cleavage of pro-opiocortin, nimodipine , which reduces adrenal gland responsiveness to ACTH , might reflexly increase beta-EP release from hypophysis.”
“Intravenous injection of nimodipine (1, 10 and 100 micrograms/Kg) determined a sharp and short-lasting increase in plasma ACTH levels.”
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