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Last Updated: 2 years ago

Possible Interaction: Nimodipine and Adrenocorticotropic Hormone

Research Papers that Mention the Interaction

Subsequent application of corticotropin in the presence of nimodipine failed to produce an enhancement of I(Ca), suggesting that corticotropin acts selectively on L-type channels.
Molecular pharmacology  •  2001  |  View Paper
We found that nimodipine markedly inhibited ACTH release at all intervals tested, whereas omega-Agatoxin IVA, omega-Conotoxin MVIIC, and omega-Conotoxin GVIA had no significant effect.
Endocrinology  •  1996  |  View Paper
Perifusing 0.2 mM nimodipine , a dihydropyridine Ca2+ channel blocker, before and after restoration of Ca2+ to the Ca2(+)-free medium inhibited ACTH release by 40-48%, and the blockade persisted for at least 70 min after nimodipine was removed from the medium.
Endocrinology  •  1990  |  View Paper
Although treatment with CRF does not alter the concentration of cell-associated calcium in D16 cells, ACTH secretion stimulated by both CRF and elevated medium K+ are inhibited by nimodipine in a dose-related manner.
Life sciences  •  1986  |  View Paper
Since glucocorticoids feedback regulates biosynthesis and cleavage of pro-opiocortin, nimodipine , which reduces adrenal gland responsiveness to ACTH , might reflexly increase beta-EP release from hypophysis.
Pharmacological research communications  •  1984  |  View Paper
Intravenous injection of nimodipine (1, 10 and 100 micrograms/Kg) determined a sharp and short-lasting increase in plasma ACTH levels.
Research communications in chemical pathology and pharmacology  •  1983  |  View Paper