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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Niflumic Acid
supplement:
Taurine
Research Papers that Mention the Interaction
“Topically applied anion channel blockers 4,4′-diisothiocyanatostilbene-2,2′-disulfonic acid (1 mM); 4-acetamido-…,2-disulfonic acid (2 mM); 5-nitro-2-(3-phenylpropylamino) benzoic acid (350 μM); niflumic acid (500 μM); tamoxifen (20 μM) and arachidonic acid (…) all significantly reduced the hyposmotically-induced release of taurine.”
Effects of Anion Channel Blockers on Hyposmotically Induced Amino Acid Release From the In Vivo Rat Cerebral Cortex“Inhibition of taurine release by 5-nitro-2-(3-phenylpropylamino)benzoic acid, niflumic acid , and 4,4′-diisothiocyanatostilbene-2,2′-disulfonic acid suggests the involvement of volume-sensitive anion channels.”
“Antagonists of the Cl-/HCO3 exchange system, SITS, DIDS and niflumic acid , significantly reduced taurine release.”
“ Niflumic acid inhibited, but did not abolish ammonia-dependent taurine and glutamine efflux, and did not change glutamate efflux.”
“ NA significantly reduced the hypoosmotically induced change in pHi to 0.17 +/- 0.02 while completely blocking taurine loss.”
“Both taurine uptake and efflux were inhibited by band 3 inhibitors 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS), 4,4'-dinitrostilbene-2,2'-disulfonic acid (DNDS), niflumic acid , or furosemide.”
“Thus, NPPB (5-nitro-2-(3phenylpropy1amino)benzoic acid), DIOA (R(+)-[(2-n-butyl4,7dichloro-…-2,3dihydro-1-oxo-l H-inden-5-yl),oxy]acetic acid), niflumic acid and DIDS (4,4'…,2'disulphonic acid) inhibited taurine efflux with the order of potency … 2 DlOA > niflumic acid 2 DIDS.”
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