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Last Updated: 3 months ago

Possible Interaction: Niflumic Acid and Calcium Supplement

Research Papers that Mention the Interaction

This hyperpolarization, which was absent in non-transfected cells, was enhanced if I(Cl Ca ) was blocked with niflumic acid.
Cell calcium  •  1997  |  View Paper
It is concluded that NFA induces a release of intracellular calcium from the Ca(2+) stores and the released intracellular calcium in turn causes concentration-dependent and reversible hyperpolarization and evokes outward currents in the SMCs of the cochlear SMA via activation of the Ca(2+)-activated potassium channels.
Sheng li xue bao : [Acta physiologica Sinica]  •  2008  |  View Paper
ICl Ca was inhibited by niflumic acid (100 μm), 5-Nitro-2-(3-phenylpropylamino)benzoic acid (NPPB, 100 μm) and 4,4′-diisothiocyano-2,2′-stilbenedisulfonic acid (DIDS, 100 μm), niflumic acid being the most potent inhibitor.
The Journal of Membrane Biology  •  1998  |  View Paper
4,4'-Diisothiocyanatostilbene-2,2'-disulphonic-acid (DIDS) and niflumic acid inhibited Icl, Ca in a voltage-dependent manner, i.e. they exerted a more potent block at positive potentials.
The Journal of physiology  •  1997  |  View Paper
In freshly dispersed portal vein cells clamped at -60 mV in caesium (Cs+)-containing solutions, niflumic acid (1-100 microM) inhibited calcium (Ca2+)-activated chloride currents (IC1(Ca)) induced by caffeine (10 mM) and by noradrenaline (10 microM).
European journal of pharmacology  •  1996  |  View Paper
In addition, niflumic acid caused intracellular Ca concentration to decrease by 16 nM and fluid transport rate to increase by 1.5 microliters.cm-2.h-1.
The American journal of physiology  •  1996  |  View Paper