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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Niflumic Acid
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“This hyperpolarization, which was absent in non-transfected cells, was enhanced if I(Cl Ca ) was blocked with niflumic acid.”
Functional effects of expression of hslo Ca2+ activated K+ channels in cultured macrovascular endothelial cells.“It is concluded that NFA induces a release of intracellular calcium from the Ca(2+) stores and the released intracellular calcium in turn causes concentration-dependent and reversible hyperpolarization and evokes outward currents in the SMCs of the cochlear SMA via activation of the Ca(2+)-activated potassium channels.”
Niflumic acid hyperpolarizes the smooth muscle cells by opening BK(Ca) channels through ryanodine-sensitive Ca(2+) release in spiral modiolar artery.“In mouse olfactory epithelium, we found that >80% of the summated electrical response to odors is blocked by niflumic acid or flufenamic acid, each of which inhibits Ca2+ -activated Cl- channels in ORNs.”
“ICl Ca was inhibited by niflumic acid (100 μm), 5-Nitro-2-(3-phenylpropylamino)benzoic acid (NPPB, 100 μm) and 4,4′-diisothiocyano-2,2′-stilbenedisulfonic acid (DIDS, 100 μm), niflumic acid being the most potent inhibitor.”
“4,4'‐Diisothiocyanatostilbene‐2,2'‐disulphonic‐acid (DIDS) and niflumic acid inhibited Icl, Ca in a voltage‐dependent manner, i.e. they exerted a more potent block at positive potentials.”
“In addition, niflumic acid caused intracellular Ca concentration to decrease by 16 nM and fluid transport rate to increase by 1.5 microliters.cm-2.h-1.”
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