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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nifedipine
supplement:
Tubocurarine
Research Papers that Mention the Interaction
“The force potentiating actions of nifedipine persisted in a calcium-free bathing solution and were enhanced by d-tubocurarine.”
Effect of nifedipine on the contractile function of the rat diaphragm in vitro.“Both verapamil and nifedipine significantly decreased the I50 and I90 of d-tubocurarine (d-Tc), pancuronium, vecuronium, and atracurium in vitro and those of the first three MR in vivo (P > 0.001).”
“However, in concentrations which had little effect on twitch response, diltiazem (20 microM) and nifedipine (50 microM) both increased the neuromuscular blockade produced by tubocurarine , gallamine and pancuronium by about 2-fold.”
“… nifedipine (29-1015 microM) and diltiazem (22-572 microM) reduced, in a dose-dependent manner, the amplitude of indirectly-… Hz with 5-10 V and 0.2 msec pulse duration, and increased the neuromuscular blockade produced by d-tubocurarine (1-254 microM), gallamine (0.… (0.01-7.0 microM).”
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