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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nifedipine
supplement:
St John's Wort
Research Papers that Mention the Interaction
“Clinical trials indicate …’s wort Hypericum perforatum ), via cytochrome P450 (CYP) and/or P-glycoprotein induction, reduces the plasma concentrations (and/or increases the …, amitriptyline, atorvastatin, chlorzoxazone, ciclosporin, debrisoquine, digoxin, erythromycin, fexofenadine, gliclazide, imatinib, indinavir, irinotecan, ivabradine, mephenytoin, methadone, midazolam, nifedipine , omeprazole, oral contraceptives, quazepam, …, verapamil, voriconazole and warfarin.”
Interactions Between Herbal Medicines and Prescribed Drugs“ St. John's wort was shown to induce NIF metabolism with increased plasma concentrations of DNIF.”
“In the rats treated with multiple administrations (15 mg/kg/d) of St. John's wort extract (SJW) for 2 weeks, the plasma concentration of NF after oral administration was significantly decreased.”
Apocynum venetum extract does not induce CYP3A and P-glycoprotein in rats.
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