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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Nifedipine
supplement:
Quercetin
Research Papers that Mention the Interaction
“Although quercetin delayed the time to peak nifedipine concentration (1.3 h) it did not alter the AUC of either the parent drug (mean 209 ng ml(-1) h) or its first-pass metabolite.”
Quercetin, an in vitro inhibitor of CYP3A, does not contribute to the interaction between nifedipine and grapefruit juice.“A 50-gmol/1 concentration of quercetin inhibited approximately 70% of felodipine and 50% of nifedipine metabolism.”
“In mechanistic in vitro studies with human liver microsomes, quercetin has been shown to be the most potent inhibitor of nifedipine and felodipine metabolism [7].”
“However, preincubation of the tissues with nifedipine (10-7 M) significantly suppressed (p < 0.05) or attenuated the initial stimulant effect of quercetin , suggesting that the flavonoid might be activating L-type voltage-dependent calcium channels.”
Dual effect of quercetin on rat isolated portal vein smooth muscle contractility“In the presence of nifedipine , the responses to apigenin, luteolin, and quercetin were significantly inhibited, but relaxation to chrysin, fisetin, and 3,3',4'-trihydroxyflavone was unaffected.”
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