Possible Interaction: Nifedipine and Progesterone

“The action of nifedipine in delaying labor is impeded by progesterone.”

“We investigated how progesterone and salmeterol modify the effect of nifedipine in an in vivo preterm birth model in rats, and how terbutaline and nifedipine modify the contractions of the isolated human myometrium.”

“Some preliminary data, however, suggest that some of the interindividual variation seen in response to medications given for the prevention progesterone ) and the treatment ( nifedipine , terbutaline, and others) of preterm labour may be caused by pharmacogenomic effects.”

“Addition of nifedipine , a typical substrate of CYP3A4, inhibited the 6 beta- and 16 alpha-hydroxylation of progesterone by CYP3A4.”

“The addition of nifedipine (10 and 100 nM), either at time 0 or just prior to progesterone introduction, significantly inhibited both DAG formation and exocytosis, suggesting that Ca2+ channels are involved in the responses observed.”

“The ability of progesterone , GABA, or muscimol to stimulate exocytosis was blocked by the Ca2+ channel antagonists verapamil or nifedipine.”

“Our results suggest that in ovariectomized rats the effects of both nifedipine and DES are similar, but 17 beta-estradiol and progesterone produce a contrary effect on the relaxation induced by nifedipine and DES (by increasing the nifedipine and decreasing the DES effects).(ABSTRACT TRUNCATED AT 250 WORDS)”

“A twofold increase in the potency of nifedipine as an inhibitor of uterine contractions was observed in rats treated with oestrogen or oestrogen plus progesterone compared with rats treated with corn oil.”