Possible Interaction: Nifedipine and Potassium

“SummaryLong term treatment with nifedipine and nitrendipine, but not verapamil and diltiazem, may reduce plasma potassium levels in hypertensive patients.”

“2 Tolmesoxide, Rx71112 and nifedipine caused a concentration‐related inhibition of noradrenaline (NA)‐ and potassium (K+)‐induced contractions in human veins.”

“The calcium channel antagonists, nifedipine , verapamil and diltiazem (0.01-10 microM), inhibited responses to high potassium , and the initial phase of shortening and lengthening responses to noradrenaline.”

“ Potassium chloride-induced contractions were completely inhibited by the calcium channel blockers diltiazem and nifedipine or by excluding Ca2+ from the medium.”

“rizine, flunarizine and nifedipine at doses antagonist activity, it has been speculated able to block calcium channels lowered the that either or both of these properties could total tritium overflow elicited by potassium.”

“After incubation with nifedipine at 2.9 X 10(-6)M, the contractions caused by LTC4, LTD4, PGF2 alpha, and potassium were significantly decreased.”

“The effect of nifedipine on potassium contraction was significantly greater than that on LTC4, LTD4, and PGF2 alpha-induced contractions.”

“Both nifedipine and nimodipine effectively inhibited contractions induced by calcium in pial arteries pretreated in a calcium-free medium and depolarised by potassium.”

“In pial arteries the calcium antagonists nifedipine and nimodipine caused an almost complete relaxation of contractions induced by potassium at drug concentrations relaxing prostaglandin F2α-contracted vessels to only about 60%.”

“ Nifedipine had a higher potency for relaxing cerebral than mesenteric arteries contracted by potassium (p < 0.001).”

“ Nifedipine was, however, a potent inhibitor of hand vein contractions induced by high concentrations of potassium provided that the noradrenergic component of the response was suppressed by simultaneous infusion of phentolamine.”

“ Nifedipine in concentrations which completely relaxes arterial and venous preparations contracted by potassium , had only a slight relaxing effect on digoxin induced contraction.”

“In contrast to verapamil, nifedipine caused a more pronounced inhibition of the potassium than of the noradrenaline evoked contractions in both arteries and veins.”

“The calcium antagonists verapamil (2.2 x 10(-7)-2.2 x 10(-5)M) and nifedipine (2.9 x 10(-8)-2.9 x 10(-6)M) relaxed both arteries and veins contracted by noradrenaline or potassium , and reduced the responses to these agents when added 15 min.”