supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Nifedipine
supplement:
Oxytocin
Research Papers that Mention the Interaction
“ Nifedipine significantly decreased cervical tissue muscle force compared to timed … of 10(-5) mol/L (vehicle 47% ± 15% vs oxytocin + nifedipine 24% ± 16%, P = .007), 10(-4) mol/L (vehicle 46% ± 16% vs oxytocin + nifedipine -… 10(-3) mol/L (vehicle 42% ± 14% vs oxytocin + nifedipine -15% ± 18%, P = .0006).”
A new paradigm for the role of smooth muscle cells in the human cervix.“In conventional concentration–effect experiments, both the mean contractile force (MCF) and the maximum amplitude of contractions induced by 1 nmol/L oxytocin were inhibited by nifedipine.”
“The voltage-sensitive calcium channel blockers nicardipine, nifedipine , and nitrendipine had similar effects, causing significant suppression of the increase in [Ca2+]i induced by oxytocin.”
“In preparations of pregnant human myometrium, normally polarized or potassium depolarized, oxytocin induced a contractile activity that was effectively inhibited by nifedipine.”
“Oxytocin produced concentration-dependent-contraction … response curves (DRCs) of oxytocin … nifedipine (1 μM), in Ca2+-free Ringer Locke solution (RLS), ruthenium red (30 μM), ruthenium red + nifedipine, cyclopiazonic acid (CPA; …-73122 (1 μM) + nifedipine and SKF96365 (25 μM) on uteri of non-pregnant and pregnant (early and mid) animals.”
Functional involvement of protein kinase C, Rho-kinase and TRPC3 decreases while PLC increases with advancement of pregnancy in mediating oxytocin-induced myometrial contractions in water buffaloes (Bubalus bubalis).“ Nifedipine reduced the PGF2α and OXT increased tension by 65.8% and 49.4%, respectively.”
“ Nifedipine reduced these effects of PGF2α and OXT by 45.3% and 39.6%.”
“After treatment with nifedipine or thapsigargin, the response to oxytocin was severely impaired.”
“Similarly, the response to OA was unaffected in the presence of nifedipine at a concentration (1 microM) which completely or highly blocked the response to KCl (60 mM), oxytocin (1 microM), or acetylcholine (100 microM).”
“2 Relaxin (0.2–6.3 nM), levcromakalim (25–800 nM), salbutamol (1–63 nM) and nifedipine (1–250 nM) caused concentration‐dependent inhibition of the spasm evoked by oxytocin (0.2 nM) and relaxin was the most potent relaxant.”
“Uterine spasm dependent upon intracellular Ca2+ was elicited by oxytocin (20 nM) in the presence of nifedipine (500 nM).”
“Calcium channel blockers verapamil (2, 10nM), diltiazem (11, 22nM), nifedipine (2.9, 14nM) and salbutamol (21, 42nM) produced concentration dependent inhibition of oxytocin induced contractions in non-pregnant rats.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback