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Last Updated: 2 years ago

Possible Interaction: Nifedipine and Kaempferol

supplement:

Kaempferol

Research Papers that Mention the Interaction

Improvement of bioavailability of nifedipine by kaempferol may be mainly because of the inhibition of the P-gp-mediated efflux transporter in the small intestine and CYP3A4-mediated metabolism in the small intestine or liver, or both.
Moreover, the absolute bioavailability (AB) and relative bioavailability (RB) of nifedipine in the presence of kaempferol was significantly higher than those of the control group after oral and intravenous administration.
Chinese journal of natural medicines  •  2019  |  View Paper
CONCLUSION The concomitant oral use of ka mpferol wi th NFP ma y influence the pharmacokinetic parameters of NFP in rats, which suggests that kaempferol might reduce the first-pass metabolism of NFP.
The C(max), AUC(0-8) and the mean retention time (MRT(0-8)) of NFP were significantly increased by simultaneous oral treatment with kaempferol (P<0.01).
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences  •  2006  |  View Paper
In endothelium-disrupt rings, kaempferol (10 μM) also enhanced the relaxation caused by isoproterenol, sodium nitroprusside, levcromakalim and nifedipine.
Molecular and Cellular Biochemistry  •  2005  |  View Paper
In the presence of nifedipine , the responses to apigenin, luteolin , and quercetin were significantly inhibited, but relaxation to chrysin, fisetin, and 3,3',4'-trihydroxyflavone was unaffected.
Journal of cardiovascular pharmacology  •  2000  |  View Paper