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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nifedipine
supplement:
Kaempferol
Research Papers that Mention the Interaction
“Improvement of bioavailability of nifedipine by kaempferol may be mainly because of the inhibition of the P-gp-mediated efflux transporter in the small intestine and CYP3A4-mediated metabolism in the small intestine or liver, or both.”
“Moreover, the absolute bioavailability (AB) and relative bioavailability (RB) of nifedipine in the presence of kaempferol was significantly higher than those of the control group after oral and intravenous administration.”
Role of kaempferol to increase bioavailability and pharmacokinetics of nifedipine in rats.“CONCLUSION The concomitant oral use of ka mpferol wi th NFP ma y influence the pharmacokinetic parameters of NFP in rats, which suggests that kaempferol might reduce the first-pass metabolism of NFP.”
“The C(max), AUC(0-8) and the mean retention time (MRT(0-8)) of NFP were significantly increased by simultaneous oral treatment with kaempferol (P<0.01).”
[Effect of kaempferol on the pharmacokinetics of nifedipine in rats].“In endothelium-disrupt rings, kaempferol (10 μM) also enhanced the relaxation caused by isoproterenol, sodium nitroprusside, levcromakalim and nifedipine.”
“In the presence of nifedipine , the responses to apigenin, luteolin , and quercetin were significantly inhibited, but relaxation to chrysin, fisetin, and 3,3',4'-trihydroxyflavone was unaffected.”
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