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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nifedipine
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“Consistently, we found that nifedipine restores the number of TH-positive neurons reduced by iron dextran overload and prevents increase of iron content in the SN.”
“These results suggested that nifedipine may suppress iron toxicity in dopamine neurons and prevent neurodegeneration.”
Nifedipine Prevents Iron Accumulation and Reverses Iron-Overload-Induced Dopamine Neuron Degeneration in the Substantia Nigra of Rats“Recently, we have shown that the calcium channel blocker nifedipine can mobilize tissue iron in mouse models of iron overload.”
“We speculated that nifedipine might inhibit the TfR1/ DMT1 (transferrin receptor 1/divalent metal transporter1)-mediated iron uptake by proximal tubule cells in addition to blocking L-type Ca2+ channels, leading to an increase in iron in lumen-fluid and then urinary iron excretion.”
Nifedipine Increases Iron Content in WKPT-0293 Cl.2 Cells via Up-Regulating Iron Influx Proteins
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