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Last Updated: 4 months ago

Possible Interaction: Nifedipine and Ginkgo Biloba Whole

Research Papers that Mention the Interaction

Accordingly, it was concluded that GBE and NFP should not be simultaneously ingested as much as possible, and careful monitoring is needed when administering NFP concomitantly with GBE to humans.
The mean heart rate after oral administration of NFP with GBE tended to be faster than that without GBE at every time point.
Biological & pharmaceutical bulletin  •  2004  |  View Paper
Ginkgo biloba L. induces both CYP3A4 and CYP2C9 and alters the AUC and Cmax of conventional medications including midazolam, tolbutamide, lopinavir and nifedipine.
Current topics in medicinal chemistry  •  2019  |  View Paper
However, the maximal plasma NFP concentration, the area under the concentration-time curve and absolute bioavailability after oral administration of NFP (5 mg/kg) were significantly increased by simultaneous oral treatment with GBE , approximately 1.6-fold, 1.6-fold and 2.1-fold, respectively.
These results suggest that the concomitant oral use of GBE appeared to reduce the first-pass metabolism of orally administered NFP , by inhibiting CYP3A, possibly but not P-gp, in rats.
Biological & pharmaceutical bulletin  •  2004  |  View Paper